BAP1, BRCA1 associated protein 1, 8314

N. diseases: 299; N. variants: 72
Disease: Tumor Progression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 Biomarker phenotype BEFREE Therefore, BAP1 functions as a tumor suppressor and limits tumor progression in melanoma. 30156010 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 Biomarker phenotype BEFREE These findings show that Bap1 regulates lineage commitment through H3K27ac-mediated transcriptional activation, at least in part, by modulation of Hdac4, and they provide insights into how BAP1 loss promotes cancer progression. 31555735 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 GeneticVariation phenotype BEFREE The most aggressive subtype expressing stemness genes has frequent BAP1 mutations, implying its pivotal role in the aggressive tumor progression. 29018224 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 AlteredExpression phenotype BEFREE With scant genomic evidence to account for these disparities, the present study sought to compare BAP1 expression between Black and White patients with clear cell RCC (ccRCC); a gene that inhibits tumor progression when overexpressed and results in poor clinical outcomes when silenced. 26854086 2016
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.050 GeneticVariation phenotype BEFREE It also demonstrated that BAP1 mutations correlate with tumor progression rather than overall survival. 25826081 2015