|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis.
|
31775794 |
2019 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibited caspase-1 suppressed the expressions of GSDMD and its cleavage form GSDMD-NT, and reduced pyroptosis in brain at day 1 and day 7 after sepsis.
|
31145977 |
2019 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, in evaluating the therapeutic effect of MT on sepsis‑induced renal injury, the results of the present study showed that MT alleviated sepsis‑induced renal injury by regulating the expression of PINK1, Parkin1, NLRP3, ASC and cleaved caspase‑1 in rats.
|
31432108 |
2019 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that 2% H<sub>2</sub> gas inhalation resulted in an increase in the 7-day survival rate, ALT and AST levels, RCR, and P62 and LC3B-II expression but decreased the histological score and FUDNC1, P-18-FUDNC1, Tim23, and caspase-1 levels after sepsis.
|
30877875 |
2019 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
After IMD<sub>1-53</sub> treatment, inflammation caused by sepsis in vivo was greatly reduced, as shown by the downregulation of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), nucleotide-binding domain and leucine-rich repeat containing family, pyrin containing 3 (NLRP3), pro-IL-1β, caspase 1, and nuclear translocation of nuclear factor-κB (NF-kB) protein levels.
|
29192367 |
2018 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Subcutaneous alum pretreatment improves survival to polymicrobial sepsis in both wild-type and T and B cell-deficient neonatal mice, but not in caspase-1/11 null mice.
|
29052227 |
2018 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Caspase-1-dependent pyroptosis of peripheral blood mononuclear cells predicts the development of sepsis in severe trauma patients: A prospective observational study.
|
29465571 |
2018 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that the genetic ablation of Tlr4, Nlrp3, and caspase-1 does not prevent the cardiac dysfunction, despite preventing the increase in pro-inflammatory cytokines, indicating that these are not feasible targets to therapy in high-grade sepsis.
|
30216298 |
2018 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that the genetic ablation of Tlr4, Nlrp3, and caspase-1 does not prevent the cardiac dysfunction, despite preventing the increase in pro-inflammatory cytokines, indicating that these are not feasible targets to therapy in high-grade sepsis.
|
29176403 |
2017 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Caspase-12 is generally recognized as a negative regulator of the inflammatory response induced by infections, because it inhibits the activation of caspase-1 in inflammasome complexes, the production of the pro-inflammatory cytokines IL-1β and IL-18 and the overall response to sepsis.
|
27142195 |
2016 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human inflammatory caspases, including caspase-1, -4, -5 and -12, are considered as key regulators of innate immunity protecting from sepsis and numerous inflammatory diseases.
|
26158519 |
2015 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent findings from population studies and animal models of infectious diseases and sepsis have uncovered a role for full-length caspase-12 in blocking the inflammatory response initiated by caspase-1, thus predisposing the organism to severe sepsis and sepsis-related lethality.
|
16977333 |
2007 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In mice, caspase-12 deficiency confers resistance to sepsis and its presence exerts a dominant-negative suppressive effect on caspase-1, resulting in enhanced vulnerability to bacterial infection and septic mortality.
|
16625199 |
2006 |