|
Pituitary hormone deficiency
|
0.300 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.
|
26764381 |
2016 |
|
Thyroid Neoplasm
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cancer-related genes transcriptionally induced by the fungicide penconazole.
|
23811263 |
2014 |
|
Thyroid Gland Follicular Adenoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cancer-related genes transcriptionally induced by the fungicide penconazole.
|
23811263 |
2014 |
|
Thyroid carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cancer-related genes transcriptionally induced by the fungicide penconazole.
|
23811263 |
2014 |
|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection.
|
30412241 |
2019 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Bone Density
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
|
29304378 |
2018 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Additionally, we show that downregulation of TCF7L1 and its paralogue TCF7L2 reduces tumor growth in a xenograft model of human skin SCC.
|
28467300 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
We identified a group of CTNNB1/TCF target genes that are activated in the absence of TCF7L1, including EPHB3, a marker of Paneth cell differentiation that has also been implicated as a tumor suppressor in CRC.
|
27333864 |
2016 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
For HNPCC tumors, the subcellular beta-catenin expression (membranous, cytoplasmic, and nuclear) correlated with the nuclear TCF-3, 4 signal in MSS tumors (Spearman correlation p < 0.0007) and MSI-H tumors (Spearman correlation p < 0.0001).
|
20532534 |
2010 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Expression and co-immunoprecipitation studies suggest that beta-catenin binds and activates tcf-3 in this tumour.
|
11437409 |
2001 |
|
Acute lymphocytic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Using primers unique for either isoform, we found that both PKCζ and PKMζ were expressed in a subset of paediatric acute lymphoblastic leukaemia (ALL) cases carrying a TCF3 (E2A) chromosomal rearrangement.
|
24990612 |
2015 |
|
Acute lymphocytic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia.
|
24997151 |
2014 |
|
Acute lymphocytic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia.
|
17311319 |
2007 |
|
Malignant neoplasm of stomach
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The transcription factor transcription factor 7-like 1 (TCF7L1) is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in gastric cancer has seldom been discussed.
|
30811526 |
2019 |
|
Stomach Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The transcription factor transcription factor 7-like 1 (TCF7L1) is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in gastric cancer has seldom been discussed.
|
30811526 |
2019 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we demonstrated that unlike its tumor-promoting effects in several other types of cancers, Tcf7l1 expression is downregulated in hepatocarcinoma compared with their adjacent nontumor counterparts.
|
31322782 |
2019 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, FOXM1, TCF7L1, E2F4 and SIN3A were revealed to be key TFs associated with HCC.
|
29658607 |
2018 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs.
|
28450117 |
2017 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
By silencing TCF7L1 expression in HCT116 cells, we show that it promotes cell proliferation and tumorigenesis in vivo by driving cell cycle progression.
|
28450117 |
2017 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2.
|
28467300 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We identified a group of CTNNB1/TCF target genes that are activated in the absence of TCF7L1, including EPHB3, a marker of Paneth cell differentiation that has also been implicated as a tumor suppressor in CRC.
|
27333864 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia.
|
24997151 |
2014 |