Angle Closure Glaucoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The present study investigated the association of single nucleotide polymorphisms (SNPs) in ZNRF3, HGF and MFRP with PACG in a northern Chinese population, as well as the association of these SNPs with the ocular biometric parameters of anterior chamber depth (ACD) and AL.
|
30348125 |
2018 |
Angle Closure Glaucoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
MFRP deficiency causes abnormal eye growth along the visual axis and significant visual comorbidities, such as angle closure glaucoma, cystic macular edema, and exudative retinal detachment.
|
29170418 |
2017 |
Angle Closure Glaucoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
We affirmed the association of PACG and combined PACS/PAC/PACG with 10 polymorphisms in 8 genes/loci, including COL11A1 (rs3753841-G, OR, 1.22; P = 0.00046), HGF (rs17427817-C, OR, 2.02; P = 6.9E-07; rs5745718-A, OR, 2.11; P = 9.9E-07), HSP70 (rs1043618, GG+GC, OR, 0.52; P = 0.0010), MFRP (rs2510143-C, OR, 0.66; P = 0.012; rs3814762-G, OR, 1.40; P = 0.0090), MMP9 (rs3918249-C, OR, 1.35; P = 0.034), NOS3 (rs7830-A, OR, 0.80; P = 0.036), PLEKHA7 (rs11024102-G, OR, 1.24; P = 8.3E-05), and PCMTD1-ST18 (rs1015213-A, OR, 1.59; P = 0.00013).
|
26854036 |
2016 |
Angle Closure Glaucoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
SNPs in the nanophthalmos gene MFRP were found to be nominally associated with PACG under the allelic model.
|
22933837 |
2012 |
Angle Closure Glaucoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
However, we found there were no statistical associations between any of the three sequence variants located on MFRP and angle-closure glaucoma.
|
18781223 |
2008 |
Angle Closure Glaucoma
|
0.060 |
GeneticVariation
|
disease |
LHGDN |
To investigate the possible involvement of CHX10 and MFRP in PACG, we sequenced both genes in PACG patients with small ocular dimensions.
|
18648522 |
2008 |
Angle Closure Glaucoma
|
0.060 |
GeneticVariation
|
disease |
LHGDN |
In our pilot study, variations that we tested in MFRP were not associated with the development of acute angle-closure glaucoma in Taiwanese subjects.
|
18781223 |
2008 |
Angle Closure Glaucoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
To investigate the possible involvement of CHX10 and MFRP in PACG, we sequenced both genes in PACG patients with small ocular dimensions.
|
18648522 |
2008 |