MFRP, membrane frizzled-related protein, 83552

N. diseases: 63; N. variants: 22
Disease: Angle Closure Glaucoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017605
Disease: Angle Closure Glaucoma
Angle Closure Glaucoma 		0.060 GeneticVariation disease BEFREE The present study investigated the association of single nucleotide polymorphisms (SNPs) in ZNRF3, HGF and MFRP with PACG in a northern Chinese population, as well as the association of these SNPs with the ocular biometric parameters of anterior chamber depth (ACD) and AL. 30348125 2018
CUI: C0017605
Disease: Angle Closure Glaucoma
Angle Closure Glaucoma 		0.060 Biomarker disease BEFREE MFRP deficiency causes abnormal eye growth along the visual axis and significant visual comorbidities, such as angle closure glaucoma, cystic macular edema, and exudative retinal detachment. 29170418 2017
CUI: C0017605
Disease: Angle Closure Glaucoma
Angle Closure Glaucoma 		0.060 GeneticVariation disease BEFREE We affirmed the association of PACG and combined PACS/PAC/PACG with 10 polymorphisms in 8 genes/loci, including COL11A1 (rs3753841-G, OR, 1.22; P = 0.00046), HGF (rs17427817-C, OR, 2.02; P = 6.9E-07; rs5745718-A, OR, 2.11; P = 9.9E-07), HSP70 (rs1043618, GG+GC, OR, 0.52; P = 0.0010), MFRP (rs2510143-C, OR, 0.66; P = 0.012; rs3814762-G, OR, 1.40; P = 0.0090), MMP9 (rs3918249-C, OR, 1.35; P = 0.034), NOS3 (rs7830-A, OR, 0.80; P = 0.036), PLEKHA7 (rs11024102-G, OR, 1.24; P = 8.3E-05), and PCMTD1-ST18 (rs1015213-A, OR, 1.59; P = 0.00013). 26854036 2016
CUI: C0017605
Disease: Angle Closure Glaucoma
Angle Closure Glaucoma 		0.060 GeneticVariation disease BEFREE SNPs in the nanophthalmos gene MFRP were found to be nominally associated with PACG under the allelic model. 22933837 2012
CUI: C0017605
Disease: Angle Closure Glaucoma
Angle Closure Glaucoma 		0.060 GeneticVariation disease BEFREE However, we found there were no statistical associations between any of the three sequence variants located on MFRP and angle-closure glaucoma. 18781223 2008
CUI: C0017605
Disease: Angle Closure Glaucoma
Angle Closure Glaucoma 		0.060 GeneticVariation disease LHGDN To investigate the possible involvement of CHX10 and MFRP in PACG, we sequenced both genes in PACG patients with small ocular dimensions. 18648522 2008
CUI: C0017605
Disease: Angle Closure Glaucoma
Angle Closure Glaucoma 		0.060 GeneticVariation disease LHGDN In our pilot study, variations that we tested in MFRP were not associated with the development of acute angle-closure glaucoma in Taiwanese subjects. 18781223 2008
CUI: C0017605
Disease: Angle Closure Glaucoma
Angle Closure Glaucoma 		0.060 Biomarker disease BEFREE To investigate the possible involvement of CHX10 and MFRP in PACG, we sequenced both genes in PACG patients with small ocular dimensions. 18648522 2008