|
Cardiac Arrest
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, B‑cell lymphoma 2 (Bcl‑2)‑associated X protein (Bax) and caspase‑3 levels were elevated and Bcl‑2 levels were decreased in the left myocardium following APE‑CA and ROSC.
|
30816437 |
2019 |
|
Cardiac Arrest
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Changes in caspase-3, hypoxia-inducible factor 1-alpha (HIF-1α), and nicotinamide adenine dinucleotide phosphate oxidase-4 (NOX4) expression were evaluated at different time points up to 72 h. Using a rat asphyxia model, we induced CA-mediated brain damage and then completed resuscitation.
|
31504040 |
2019 |
|
Cardiac Arrest
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
To explore these two hypotheses, we measured serum NfL levels by single-molecule array (Simoa) technique in 115 subjects, comprising patients with MSA-C (n = 25), SAOA (n = 25), the most frequent repeat-expansion SCAs (SCA 1, 2, 3 and 6) (n = 20), and age-matched controls (n = 45).
|
29737427 |
2018 |
|
Cardiac Arrest
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our results show that CA amplified autophagy and apoptotic Caspase-3/Caspase-9, and downregulated Nrf2-ARE pathway in the hippocampus CA1 region.
|
29750875 |
2018 |
|
Cardiac Arrest
|
0.090 |
Biomarker
|
disease |
BEFREE |
In conclusion, activation of mTOR signal is engaged in pathophysiological process during CA-induced transient global ischemia and blocking mTOR pathway plays a beneficial role in regulating injured neuronal tissues and neurological deficits via PIC, apoptotic Caspase-3 and VEGF mechanisms.
|
28729914 |
2017 |
|
Cardiac Arrest
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Subclinical neuropathy is an important feature of spinocerebellar ataxias (SCA) but the true prevalence and electrophysiological characteristics in genetically proven patients of SCA 1, 2 and 3 are largely unknown.
|
21880333 |
2012 |
|
Cardiac Arrest
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Four hundred seventy-six unrelated patients with suspected SCA underwent genetic testing for SCA 1, 2, 3, 6, 7, 8, 10, 12, 17, and DRPLA gene mutations.
|
17300808 |
2007 |
|
Cardiac Arrest
|
0.090 |
Biomarker
|
disease |
BEFREE |
SCA 3 was identified in 31 (53.4%) patients from 15 families, SCA 2 in 17 (29.3%) patients from 12 families and SCA 1 in four (6.9%) patients from four families.Other SCA subtypes were rare.
|
12485197 |
2002 |
|
Cardiac Arrest
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
To date, two SCA loci have been identified-one locus (SCA-1) on the short arm of chromosome 6 and the second locus (SCA-2) on the long arm of chromosome 12.
|
8178818 |
1994 |