Malignant Neoplasms
|
0.090 |
PosttranslationalModification
|
group |
BEFREE |
In the lungs, acrylamide exposure resulted in a decrease of histone H4 lysine 20 trimethylation (H4K20me3), a common epigenetic feature of human cancer, while in the livers, there was increased acetylation of histone H3 lysine 27 (H3K27ac), a gene transcription activating mark.
|
30807115 |
2019 |
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
This approach is validated on different types of samples, including formalin-fixed paraffin-embedded pathology tissues, and employed to profile histone H4 modifications in cancer samples and normal tissues, identifying previously reported differences, as well as novel ones.
|
30471193 |
2019 |
Primary malignant neoplasm
|
0.090 |
Biomarker
|
group |
BEFREE |
This approach is validated on different types of samples, including formalin-fixed paraffin-embedded pathology tissues, and employed to profile histone H4 modifications in cancer samples and normal tissues, identifying previously reported differences, as well as novel ones.
|
30471193 |
2019 |
Primary malignant neoplasm
|
0.090 |
PosttranslationalModification
|
group |
BEFREE |
In the lungs, acrylamide exposure resulted in a decrease of histone H4 lysine 20 trimethylation (H4K20me3), a common epigenetic feature of human cancer, while in the livers, there was increased acetylation of histone H3 lysine 27 (H3K27ac), a gene transcription activating mark.
|
30807115 |
2019 |
Malignant Neoplasms
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Methylation of histone H4 lysine 20 (H4K20) has been associated with cancer.
|
29616094 |
2018 |
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Abbreviations: ALS: Amyotrophic Lateral Sclerosis; APP: Amyloid Precursor Protein gene; CASP3: Caspase 3 gene; CASP9: Caspase 9 gene; H2AFX: H2A histone family, member X gene; HIST1H2AL: Histone H2A type 1 gene; HIST1H2BK: Histone H2B type 1-K gene; HIST1H3J: Histone H3J gene; HIST1H4B: Histone H4B gene; HIST2H2BE: Histone H2B type 2-E gene; HUGO: human genome organization; KM: Kaplan-Meier survival curve; MAPT: Tau gene; OV: Ovarian cancer; SNCA: alpha-syneculin gene; TARDBP: Transactive response DNA binding protein 43 kDa; TCGA: the cancer genome atlas.
|
30394813 |
2018 |
Primary malignant neoplasm
|
0.090 |
Biomarker
|
group |
BEFREE |
Abbreviations: ALS: Amyotrophic Lateral Sclerosis; APP: Amyloid Precursor Protein gene; CASP3: Caspase 3 gene; CASP9: Caspase 9 gene; H2AFX: H2A histone family, member X gene; HIST1H2AL: Histone H2A type 1 gene; HIST1H2BK: Histone H2B type 1-K gene; HIST1H3J: Histone H3J gene; HIST1H4B: Histone H4B gene; HIST2H2BE: Histone H2B type 2-E gene; HUGO: human genome organization; KM: Kaplan-Meier survival curve; MAPT: Tau gene; OV: Ovarian cancer; SNCA: alpha-syneculin gene; TARDBP: Transactive response DNA binding protein 43 kDa; TCGA: the cancer genome atlas.
|
30394813 |
2018 |
Primary malignant neoplasm
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Methylation of histone H4 lysine 20 (H4K20) has been associated with cancer.
|
29616094 |
2018 |
Malignant Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
In normal RWPE-1 cells and even stronger in cancer DU145 cells, the combined treatment induced both AR gene expression on the mRNA level and increased histone H4 acetylation in AR gene promoter.
|
27499010 |
2016 |
Primary malignant neoplasm
|
0.090 |
AlteredExpression
|
group |
BEFREE |
In normal RWPE-1 cells and even stronger in cancer DU145 cells, the combined treatment induced both AR gene expression on the mRNA level and increased histone H4 acetylation in AR gene promoter.
|
27499010 |
2016 |
Malignant Neoplasms
|
0.090 |
PosttranslationalModification
|
group |
BEFREE |
The genome-wide loss of histone H4 lysine 20 tri-methylation (H4K20me3) is observed in multiple types of cancer, including breast tumors.
|
25814362 |
2015 |
Primary malignant neoplasm
|
0.090 |
PosttranslationalModification
|
group |
BEFREE |
The genome-wide loss of histone H4 lysine 20 tri-methylation (H4K20me3) is observed in multiple types of cancer, including breast tumors.
|
25814362 |
2015 |
Malignant Neoplasms
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Alterations in histone H4 lysine 20 methylation: implications for cancer detection and prevention.
|
22035019 |
2012 |
Primary malignant neoplasm
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Alterations in histone H4 lysine 20 methylation: implications for cancer detection and prevention.
|
22035019 |
2012 |
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Global profiling of histone changes in some human cancers demonstrated that loss of histone H4 acetylation at lysine16 (H4KA16) and trimethylation at lysine 20 (H4KM20) was a common hallmark of cancer.
|
21415707 |
2011 |
Primary malignant neoplasm
|
0.090 |
Biomarker
|
group |
BEFREE |
Global profiling of histone changes in some human cancers demonstrated that loss of histone H4 acetylation at lysine16 (H4KA16) and trimethylation at lysine 20 (H4KM20) was a common hallmark of cancer.
|
21415707 |
2011 |
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.
|
15765097 |
2005 |
Primary malignant neoplasm
|
0.090 |
Biomarker
|
group |
BEFREE |
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.
|
15765097 |
2005 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Beside H4K20me3, plasma histone H4 is a useful marker to discriminate colonic tumors from precancerous polyps and other conditions.
|
31471419 |
2020 |
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype.
|
29308302 |
2018 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Further, we demonstrate that the observed hypo-acetylation of histone H4 in tissue and serum samples of tumor bearing animals corroborated with the elevated HDAC activity in both samples compared to normal.
|
28360947 |
2017 |
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Whereas the levels of H4 and histone acetyltransferases were stable irrespective of HRD status, the levels of histone H4 acetylation and one HDAC, HDAC6, were elevated in the HRD tumors.
|
28866885 |
2017 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
SET domain containing (lysine methyltransferase) 8 (SET8) is the sole lysine methyltransferase that catalyzes the monomethylation of histone H4 lysine 20, and is associated with tumor growth, invasion and metastasis.
|
29250163 |
2017 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Global analysis of activated regions of the genome, as defined by differential acetylation of histone H4 (H4ac), revealed that the cell death pathway was significantly dysregulated in RBPJ-depleted tumors.
|
25512468 |
2015 |
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Aberrant expression of Fhit and acetylated histone H4 are frequently associated with the presence of esophageal squamous cell carcinoma, and they are potential prognostic predictors for patients after resection of the tumor.
|
16863736 |
2006 |