H4C12, H4 clustered histone 12, 8362

N. diseases: 121; N. variants: 1
Disease: leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia 		0.020 GeneticVariation disease BEFREE The expression of one of the nine mammalian PRMTs, PRMT5, affects the levels of symmetric dimethylarginine (SDMA) at Arg-3 on histone H4, leading to the repression of genes which are related to disease progression in lymphoma and leukemia. 28874563 2017
CUI: C0023418
Disease: leukemia
leukemia 		0.020 AlteredExpression disease BEFREE In addition, our study has shown that Belinostat and DZNep together with RA caused a depletion in HDAC1 and HDAC2 protein levels, HDAC2 gene expression and increased hyperacetylation of histone H4 in both leukemia cell lines. 28192098 2017