|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Circular RNA itchy E3 ubiquitin protein ligase (circ-ITCH), a novel circular RNA originated from several exons of ITCH and located on chromosome 20q11.22, was proved to be declined in many malignant tumors, such as melanoma and ovarian cancer, resulting in tumor occurrence and progression.
|
31843532 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our combined results show for the first time that circ-ITCH is a tumor suppressor, a promising prognostic biomarker in TNBC and that its restoration could well be a successful strategy in TNBC.
|
30509108 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Background:</b> Circular RNA ITCH has been proved as a tumor suppressor in several types of cancer.
|
31403357 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It was reported that circ-ITCH is downregulated in multi cancers and serves as a powerful tumor suppressor among through a competing endogenous RNA (ceRNA) pathway.
|
30243714 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For example, ciRS-7 plays a role in tumor promotion and circ-ITCH acts as a tumor suppressor.
|
30077838 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Usp9x inhibition by shRNA-knockdown or by G9 treatment reduced 3D colony formation in PANC1 and PDX cell lines, induced rapid apoptosis in MIAPACA2 cells, and associated with reduced Mcl-1 and ITCH protein levels.
|
29248719 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Circ-ITCH correlates with small tumor size, decreased FIGO stage and prolonged OS, and it inhibits cells proliferation while promotes cells apoptosis in EOC.
|
30347599 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Consistent with this enhanced turnover, Itch<sup>a18H/a18H</sup> mice carrying the Min mutation (Itch<sup>a18H/a18H</sup>; Apc<sup>Min/+</sup>) displayed a 76% reduction in tumor burden as compared to Apc<sup>Min/+</sup> littermates with normal levels of ITCH.
|
29309986 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
circ-ITCH acts as a tumor suppressor by a novel circ-ITCH/miR-17, miR-224/p21, PTEN axis, which may provide a potential biomarker and therapeutic target for the management of BCa.
|
29386015 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Real-time PCR was used to detect the expression of ITCH mRNA in the tumor tissues and paracarcinoma tissues from 32 patients with lung cancer.
|
30078010 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The E3 ubiquitin ligase ITCH has been previously reported to inhibit the tumor suppressive Hippo signaling by suppressing LATS1/2 in breast cancer and chronic lymphocytic leukemia.
|
26621835 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
When co-administered with gemcitabine (100 mg/kg/week) at a subtherapeutic dose, treatment with ITCH-shRNA (3x 50 mg/week) was able to fully suppress tumour growth for 17 days, suggesting that downregulation of ITCH mediated by DAB-Am16/shRNA sensitizes pancreatic cancer to gemcitabine in an efficient and specific manner.
|
25267700 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway.
|
25350971 |
2014 |