BCO2, beta-carotene oxygenase 2, 83875

N. diseases: 19; N. variants: 7
Disease: Malignant neoplasm of prostate ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.020 GeneticVariation disease BEFREE Although Bco2 genotype alone did not significantly change prostate cancer outcome in the control AIN-93G-fed mice, the abilities of lycopene and tomato feeding to inhibit prostate carcinogenesis were significantly attenuated by the loss of Bco2 (P<sub>interaction</sub> = 0.0004 and 0.0383, respectively). 27807077 2017
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.020 Biomarker disease BEFREE BCO2-mediated inhibition of NF-κB signaling implies BCO2 status is important in prostate cancer progression. 27406826 2016