STK40, serine/threonine kinase 40, 83931

N. diseases: 6; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1319315
Disease: Adenocarcinoma of large intestine
Adenocarcinoma of large intestine 		0.300 GeneticVariation disease UNIPROT
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.100 GeneticVariation disease GWASDB Dosage transmission disequilibrium test (dTDT) for linkage and association detection. 23691058 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 Biomarker group BEFREE In addition, STK40 knockdown impaired growth in an anchorage-independent manner <i>in vitro</i> and slowed tumor growth <i>in vivo</i>. 29854300 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 Biomarker group BEFREE Additionally, Fbxw7, Pdcd4, and Stk40 (tumor-suppressor targets of miR-223, -21, and -31) were downregulated in marked-ZD cohort. 26918602 2016
CUI: C3539878
Disease: Triple Negative Breast Neoplasms
Triple Negative Breast Neoplasms 		0.010 Biomarker disease BEFREE These findings identify the largely uncharacterized putative protein kinase STK40 as a novel candidate treatment target for TNBC. 29854300 2018
CUI: C0002871
Disease: Anemia
Anemia 		0.010 GeneticVariation disease BEFREE Here we report that targeted deletion of Stk40 leads to fetal liver hypoplasia and anemia in the mouse embryo. 28358362 2017
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.010 Biomarker disease BEFREE microRNA-130a Promotes Human Keratinocyte Viability and Migration and Inhibits Apoptosis Through Direct Regulation of STK40-Mediated NF-κB Pathway and Indirect Regulation of SOX9-Meditated JNK/MAPK Pathway: A Potential Role in Psoriasis. 28085489 2017