Disease: Steatohepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.020 GeneticVariation disease BEFREE The splice variant IMP2-2/p62 promotes steatohepatitis and hepatocellular carcinoma. 31555647 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.020 Biomarker disease BEFREE In conclusion, hepatocyte-specific IMP2 deficiency promotes modest diet-induced fatty liver by impairing fatty acid oxidation through increased degradation of the IMP2 client mRNAs <i>PPAR</i>α and <i>CPT1A</i> This finding indicates that the previously observed marked protection against fatty liver conferred by global IMP2 deficiency in mice is entirely due to their reduced adiposity. 31209109 2019