|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of biannual versus annual azithromycin distribution for trachoma control on serological response to merozoite surface protein 1 (MSP-1<sub>19</sub>), a surrogate for malaria incidence, was evaluated among children in Niger.
|
31796025 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combining genetic characterization with the immunogenicity of merozoite surface protein-8 (MSP-8) supports considering MSP-8 as a candidate target for blood-stage vaccines against malaria.
|
30975200 |
2019 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Merozoite surface protein 7 (MSP-7) is a multigene family expressed during malaria blood-stage infection.
|
29718980 |
2018 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Epidemiology of malaria and MSP-2 gene-based genetic diversity of <i>Plasmodium falciparum</i> from patients attending community health centre, Jiribam, Manipur.
|
29063888 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that MSP-1, especially the partially conserved subunit MSP-1<sub>83</sub>, is a major target of opsonizing antibodies acquired during natural exposure to malaria.
|
28877929 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
A pool of human plasma from a malaria endemic region was collected from 140 single plasma donations selected for reactivity to Plasmodium falciparum apical membrane antigen-1 (AMA-1) and merozoite surface proteins (MSP-1<sub>19</sub>, MSP-1<sub>42</sub>, MSP-2 and MSP-3).
|
28779755 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to assess the immune responses against Plasmodium falciparum merozoite surface protein-1 (MSP-1<sub>19</sub>) and apical membrane antigen-1 (AMA-1) in children residing in the different epidemiological strata of malaria in Cameroon.
|
29121929 |
2017 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that AMA-1 and MSP-1<sub>19</sub> sero-epidemiological analysis may provide further evidence in assessing variation in malaria exposure and evaluating malaria control efforts in high endemic area.
|
28831122 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several studies of P. falciparum have reported that the C-terminus (a 42kDa fragment) of merozoite surface protein-1 (MSP-1<sub>42</sub>; consisting of MSP-1<sub>19</sub> and MSP-1<sub>33</sub>) is a potential candidate for a malaria vaccine.
|
28634105 |
2017 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
We examined RASSF1A promoter methylation in primary tumors, adjacent morphologically tumor cell-free tissues and corresponding circulating tumor DNA (ctDNA) samples of patients with HGSC, using a real-time methylation specific PCR (real-time MSP) and a methylation-sensitive high-resolution melting analysis (MS-HRMA) assay for the detection and semi-quantitative estimation of methylation, respectively.
|
28206954 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
A longitudinal study was conducted in a low endemic area in northern Tanzania to examine the influence of the α-thalassaemia trait on malaria incidence and antibody responses to malaria apical membrane antigen-1 (AMA-1) and merozoite surface protein1-19 (MSP-119).
|
25604491 |
2015 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study determines whether the presence of malaria and intestinal parasites co-infection is associated with impaired IgG responses to Plasmodium vivax AMA-1 and MSP-119 in a rural population of the Brazilian Amazon.
|
26546161 |
2015 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
In most of the earlier studies, the MSP-142 of malaria parasites was expressed as insoluble protein in inclusion bodies and it is difficult to get purified protein in conformation form.
|
25195175 |
2014 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The major MSP-119 haplotypes of P. falciparum populations in all endemic populations during three transmission seasons in Thailand were identified, providing basic information on the common haplotypes of MSP-119 that is of use for malaria vaccine development and inferring the population structure of P. falciparum populations in Thailand.
|
24521474 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the first series, analyzed by MSP, CRC stage II patients (n = 233) with RET methylated tumors had a significantly worse overall survival as compared to those with unmethylated tumors (HRmultivariable = 2.51, 95%-CI: 1.42-4.43).
|
24560444 |
2014 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to characterize and investigate the extent and maintenance of MSP-9 genetic diversity, we analyzed DNA sequences of the following malaria parasite species: Plasmodium falciparum, Plasmodium reichenowi, Plasmodium chabaudi, Plasmodium yoelii, Plasmodium berghei, Plasmodium coatneyi, Plasmodium gonderi, Plasmodium knowlesi, Plasmodium inui, Plasmodium simiovale, Plasmodium fieldi, Plasmodium cynomolgi and Plasmodium vivax and evaluated the signature of natural selection in all MSP-9 orthologs.
|
24044894 |
2013 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antibody elution efficiency was assessed by total IgG ELISA for malaria antigens apical membrane antigen-1 (AMA-1) and merozoite-surface protein-1 (MSP-142).
|
23914905 |
2013 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Except for children under 3 years, the age-matched proportions of children achieving protective threshold concentrations of antibodies against AMA1 and MSP-2 were significantly lower in Junju compared to Chonyi (Fishers exact test, P<0.01).
|
23800539 |
2013 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that inclusion of more than one MSP-119 variant may not be required in a malaria blood stage vaccine.
|
22909378 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CDKN2A (cyclin-dependent kinase inhibitor 2A or p16), SFN (stratifin or 14-3-3 σ), EDNRB (endothelin receptor B) and RUNX3 (runt-related transcript factor-3) had their methylation patterns evaluated by MSP analysis in OSCC tumors (n = 45).
|
22936053 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Promoter hypermethylation of MSH2 was analyzed using real-time methylation-specific PCR (real-time MSP) in paired tumor and plasma samples of 209 patients with esophageal squamous cell carcinoma (ESCC).
|
22265839 |
2012 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Using the sensitive assay of MSP, we explored the promoter methylation status for the three genes in tumor specimens and urine sediment DNA from 32 bladder cancer patients.
|
22992440 |
2012 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Merozoite surface protein-1 (MSP-1) and MSP-2 of Plasmodium falciparum are potential vaccine candidate antigens for malaria vaccine development.
|
20478015 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The methylation status of FHIT promoter was assessed by nested methylation-specific polymerase chain reaction (MSP-PCR) in 232 tumor and 225 normal lung samples of which a subset of 187 patients had available normal/tumor DNA pairs.
|
19096006 |
2009 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parasitemia at the time of diagnosis, rather than cumulative malaria exposure or acquired immunity (presence of variant-specific antibodies matching the MSP-2 type in infecting parasites), was a major predictor of perceived symptom severity.
|
17556615 |
2007 |