SPOP, speckle type BTB/POZ protein, 8405

N. diseases: 72; N. variants: 12
Disease: Tumor Cell Invasion ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 Biomarker phenotype BEFREE Silencing APPBP2 in A549 and H1299 cells resulted in the inhibition of cell proliferation, migration, and invasion, enhancement of apoptosis, and a significant decrease in the expression of PPM1D and SPOP. 31105033 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 Biomarker phenotype BEFREE Loss- and gain-of-function assays demonstrated that SPOP inhibited HCC cell migration and invasion in vitro. 29777712 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 AlteredExpression phenotype BEFREE SPOP promotes ATF2 ubiquitination and degradation, and ATF2 is an important mediator of SPOP inactivation-induced cell proliferation, migration and invasion. 29996942 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 Biomarker phenotype BEFREE Matrigel-coated invasion chambers were used to detect the invasion ability of SPOP in OS cells. 29461588 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 Biomarker phenotype BEFREE It exerts strong tumor-promoting effects through targeting SPOP in GC cell migration and invasion. 30174445 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 AlteredExpression phenotype BEFREE Moreover, INF2 is important for SPOP inactivation-induced prostate cancer cell migration and invasion. 28448495 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 Biomarker phenotype BEFREE More interestingly, SPOP was positive in tumors with local invasion or metastasis, and it was associated with tumor recurrence-free survival of clear cell RCC patients. 27572476 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 AlteredExpression phenotype BEFREE In vitro overexpression of SPOP markedly inhibited cell viability, migration and invasion in vitro. 25351530 2015