SPOP, speckle type BTB/POZ protein, 8405

N. diseases: 72; N. variants: 12
Disease: Clear-cell metastatic renal cell carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2931852
Disease: Clear-cell metastatic renal cell carcinoma
Clear-cell metastatic renal cell carcinoma 		0.030 AlteredExpression disease BEFREE SPOP expression was high in blood of 60% patients and in tumor tissue of 90% patients with clear cell RCC. 30197334 2018
CUI: C2931852
Disease: Clear-cell metastatic renal cell carcinoma
Clear-cell metastatic renal cell carcinoma 		0.030 Biomarker disease BEFREE These data identified SPOP as a new marker and prognostic factor for clear cell RCC, and its functions provide new insight into the molecular mechanisms of RCC progression, in which SPOP appears to be an EMT activator. 27572476 2016
CUI: C2931852
Disease: Clear-cell metastatic renal cell carcinoma
Clear-cell metastatic renal cell carcinoma 		0.030 AlteredExpression disease BEFREE SPOP expression distinguished histological subtypes of RCC and facilitated identification of clear cell RCC as the primary tumor for metastatic lesions. 19164706 2009