|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.120 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies in Africans have yielded genetic discovery that would otherwise not be possible; these include identification of novel loci associated with obesity (SEMA-4D, PRKCA, WARS2), metabolic syndrome (CA-10, CTNNA3), and T2D (AGMO, ZRANB3).
|
31520154 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.120 |
Biomarker
|
disease |
BEFREE |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.
|
31324766 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.
|
31324766 |
2019 |
|
Warburg Sjo Fledelius syndrome
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
The deletion 2q21.3 includes exons of the genes RAB3GAP1 (associated with Warburg Micro syndrome) and ZRANB3 (not disease-associated).
|
23124039 |
2013 |
|
Warburg Sjo Fledelius syndrome
|
0.110 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Hip circumference
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic loci link adipose and insulin biology to body fat distribution.
|
25673412 |
2015 |
|
Sudden Cardiac Death
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease.
|
23593153 |
2013 |
|
Congenital cataract
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Microcornea
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Hypoplasia of corpus callosum
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Sunken eyes
|
0.100 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Importantly, our findings allow us to interpret the functional significance of cancer associated ZRANB3 mutations.
|
28621305 |
2017 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Inherited mutations in SMARCAL1 cause a severe developmental disorder and mutations in ZRANB3 and HLTF are linked to cancer illustrating the importance of these enzymes in ensuring complete and accurate DNA replication.
|
28954549 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Inherited mutations in SMARCAL1 cause a severe developmental disorder and mutations in ZRANB3 and HLTF are linked to cancer illustrating the importance of these enzymes in ensuring complete and accurate DNA replication.
|
28954549 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Importantly, our findings allow us to interpret the functional significance of cancer associated ZRANB3 mutations.
|
28621305 |
2017 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, ZRANB3 plays a major role in regulating tumor invasion and H-ras<sup>G12V</sup>-promoted transformation in a manner dependent on the recently discovered interactome of RNR-α involving select cytosolic-/nuclear-localized protein players.
|
31836351 |
2020 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In a study in this issue of <i>Cancer Research</i>, Puccetti and colleagues report that mice lacking either SMARCAL1 or ZRANB3 activity have delayed development of MYC-induced B-cell lymphomas.
|
30936075 |
2019 |
|
Developmental delay (disorder)
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In a study in this issue of <i>Cancer Research</i>, Puccetti and colleagues report that mice lacking either SMARCAL1 or ZRANB3 activity have delayed development of MYC-induced B-cell lymphomas.
|
30936075 |
2019 |
|
Global developmental delay
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In a study in this issue of <i>Cancer Research</i>, Puccetti and colleagues report that mice lacking either SMARCAL1 or ZRANB3 activity have delayed development of MYC-induced B-cell lymphomas.
|
30936075 |
2019 |
|
Impaired insulin secretion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown or genomic knockout of the zebrafish ortholog results in reduction in pancreatic β-cell number which we demonstrate to be due to increased apoptosis in islets. siRNA transfection of murine Zranb3 in MIN6 β-cells results in impaired insulin secretion in response to high glucose, implicating Zranb3 in β-cell functional response to high glucose conditions.
|
31324766 |
2019 |
|
Developmental Disabilities
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Inherited mutations in SMARCAL1 cause a severe developmental disorder and mutations in ZRANB3 and HLTF are linked to cancer illustrating the importance of these enzymes in ensuring complete and accurate DNA replication.
|
28954549 |
2017 |
|
Schimke immunoosseous dysplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report that the ZRANB3 translocase, a SNF2 family member related to the SIOD disorder SMARCAL1 protein, is recruited by polyubiquitinated PCNA to promote fork restart following replication arrest.
|
22704558 |
2012 |