CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Disease: West Nile Fever ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0043124
Disease: West Nile Fever
West Nile Fever 		0.020 Biomarker disease BEFREE Our data suggests that OPN expression at early time points may provide protection against viral spread in the CNS by negatively controlling the type I IFN-sensitive, caspase 1-dependent inflammasome, while promoting an alternative caspase 8-associated pathway, to control the apoptosis of infected cells during WNV infection in the CNS. 28811681 2017
CUI: C0043124
Disease: West Nile Fever
West Nile Fever 		0.020 Biomarker disease BEFREE These results demonstrate that DR-induced apoptotic signaling is activated in the brain following WNV infection and suggest that the caspase 8-dependent cleavage of Bid promotes intrinsic apoptotic signaling within the brains of infected animals. 24198425 2014