CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Disease: Tongue Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0558353
Disease: Tongue Carcinoma
Tongue Carcinoma 		0.010 AlteredExpression disease BEFREE Real-time PCR showed that berberine stimulated gene expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G. The present study demonstrated that berberine-mediated apoptosis of SCC-4 cells is regulated by ROS, mitochondria, caspase-3-dependent and mitochondria-dependent pathways, suggesting that berberine may be considered for future studies as a promising therapeutic candidate for human tongue cancer. 19846952 2009