|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
EVA1A expression was shown to be upregulated in tissue samples from oxaliplatin-resistant HCC patients, and its ectopic expression partially induced autophagy and reversed the effect of miR-125b on inhibiting the growth of oxaliplatin-resistant cell lines and xenograft tumors.
|
29749374 |
2018 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Furthermore in vivo, overexpression of EVA1A successfully inhibited tumor growth in NOD/SCID mice.
|
28185834 |
2017 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
A decreased expression of FAM176A has been found in several types of human tumors in including lung cancers.
|
24257118 |
2014 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Cell viability analysis revealed that the adenovirus-mediated increase of TMEM166 inhibited tumor cell growth in a dose- and time-dependent manner.
|
22960574 |
2013 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In this study, we generated a specific rabbit polyclonal antibody against human TMEM166 and assessed the expression of this protein in various human normal and tumor tissue samples by tissue microarray-based immunohistochemical analysis.
|
22495369 |
2013 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
TMEM166 mRNA and protein expression demonstrated significant reduction in ESCCs compared with remote esophageal tissues, albeit with no correlation with tumour size, differentiation, stage, and lymph node metastasis, suggesting a role in regulating autophagic and apoptotic processes in the ESCC.
|
23098460 |
2012 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, suppressed EVA1A expression levels are negatively correlated with differentiation grade in 365 primary HCCs, while EVA1A-AS expression levels are positively correlated with patient survival.
|
31754186 |
2019 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Correction to: MicroRNA-125b reverses oxaliplatin resistance in hepatocellular carcinoma by negatively regulating EVA1A mediated autophagy.
|
30143606 |
2018 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
EVA1A expression was shown to be upregulated in tissue samples from oxaliplatin-resistant HCC patients, and its ectopic expression partially induced autophagy and reversed the effect of miR-125b on inhibiting the growth of oxaliplatin-resistant cell lines and xenograft tumors.
|
29749374 |
2018 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Our data suggest that EVA1A-induced autophagy and apoptosis play a role in suppressing the development of GBM and their up-regulation may be an effective method for treating this form of cancer.
|
28185834 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Our data suggest that EVA1A-induced autophagy and apoptosis play a role in suppressing the development of GBM and their up-regulation may be an effective method for treating this form of cancer.
|
28185834 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Our data indicated that Ad5-TMEM166 may be a novel gene therapy candidate for cancer.
|
22960574 |
2013 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Our data indicated that Ad5-TMEM166 may be a novel gene therapy candidate for cancer.
|
22960574 |
2013 |
|
Liver Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, for the first time, we have demonstrated that Eva1a-mediated autophagy ameliorated liver injury in mice with ALF by attenuating inflammatory responses and apoptosis, indicating a potential therapeutic application for ALF.
|
29991758 |
2018 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, gene set enrichment analysis showed that neurodegenerative diseases, such as Alzheimer's disease and Huntington's disease, were strongly associated with Eva1a knockout.
|
28044434 |
2017 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that EVA1A-induced autophagy and apoptosis play a role in suppressing the development of GBM and their up-regulation may be an effective method for treating this form of cancer.
|
28185834 |
2017 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy.
|
28151473 |
2017 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy.
|
28151473 |
2017 |
|
Huntington Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, gene set enrichment analysis showed that neurodegenerative diseases, such as Alzheimer's disease and Huntington's disease, were strongly associated with Eva1a knockout.
|
28044434 |
2017 |
|
Cardiomyopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
Data from experiments showed that loss of Eva1a in the adult heart increased cardiac fibrosis, promoted cardiac hypertrophy, and led to cardiomyopathy and death.
|
28151473 |
2017 |
|
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Data from experiments showed that loss of Eva1a in the adult heart increased cardiac fibrosis, promoted cardiac hypertrophy, and led to cardiomyopathy and death.
|
28151473 |
2017 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that EVA1A-induced autophagy and apoptosis play a role in suppressing the development of GBM and their up-regulation may be an effective method for treating this form of cancer.
|
28185834 |
2017 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Although the tissue architecture was deformed, EVA1A was absent in the alpha cells of pancreatic ductal adenocarcinomas, intraductal papillary mucinous neoplasms, mucinous cystadenomas, solid papillary tumors and pancreatic neuroendocrine tumors.
|
25640383 |
2015 |
|
Pancreatic Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The ectopic expression of EVA1A in pancreatic neoplasms may contribute to their pathogenesis and warrants further investigation.
|
25640383 |
2015 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A decreased expression of FAM176A has been found in several types of human tumors in including lung cancers.
|
24257118 |
2014 |