|
leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It was found that the variants rs10740055 of ARID5B and rs6964823 of IKZF1 act individually and additively as risk factors in the development of leukemia in the populations of Jammu and Kashmir in Northern India.
|
30810385 |
2019 |
|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Since two genome-wide association studies identified the same susceptible region at ARID5B and IKZF1 for acute leukemia in Caucasians in the same time, several research groups have confirmed the similar results in different ethnicities and of different acute leukemia subtypes (ALL and AML).
|
29292192 |
2018 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ARID5B, an AT-rich interaction domain DNA-binding motif-containing transcription factor, is expressed higher in primary PCa than normal prostate, and correlated with AR expression.
|
30027545 |
2018 |
|
Carcinogenesis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Mutations and single nucleotide polymorphisms of AT-rich interactive domain-containing protein 5B (ARID5B) are involved in the oncogenesis of acute lymphoblastic leukemia (ALL) and treatment outcomes.
|
30420689 |
2018 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ARID5B, an AT-rich interaction domain DNA-binding motif-containing transcription factor, is expressed higher in primary PCa than normal prostate, and correlated with AR expression.
|
30027545 |
2018 |
|
Pediatric Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further, we identified other biologically relevant candidate genes for pediatric obesity including ARID5B, GPR39, PTPRN2, and HNF4G.
|
29976977 |
2018 |
|
Cardiovascular Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Mediation analysis supports assumptions that ARID5B expression mediates effects of cg25953130 methylation and several cardiovascular disease risk factors on atherosclerotic burden.
|
28855511 |
2017 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Four single nucleotide polymorphisms (SNPs) in the modulator recognition factor 2/AT-rich interaction domain 5B (MRF2/ARID5B) gene located at chromosome 10q21.2 have been shown to be associated with both type 2 diabetes mellitus (T2DM) and coronary artery disease in a Japanese cohort.
|
28469100 |
2017 |
|
Leukemogenesis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.
|
29326336 |
2017 |
|
Hypoproteinemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SNPs (rs4948502, rs4948496, rs4948487) of the ARID5B gene were associated with the serum levels of MTX (P < 0·02), serum levels and area under the curve of 7-OH-MTX (P < 0·02) and with hypoproteinaemia (P = 0·004).
|
24712521 |
2014 |
|
MIXED LINEAGE LEUKEMIA
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For ARID5B (rs10821936), homozygosity for the variant allele increased risk for the ALL/MLL- subgroup only (OR = 7.2, 95% CI = 2.5-20.6).
|
22422485 |
2013 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Association of MRF2/ARID5B SNPs was investigated in 500 diabetic patients from the Department of Metabolic Diseases at the University of Tokyo and 243 hospital-based nondiabetic individuals from the Institute for Adult Disease Asahi Life Foundation Hospital and 500 community-based nondiabetic individuals from the Hiroshima Atomic Bomb Casualty Council Health Management Center.
|
22971728 |
2012 |
|
Nijmegen Breakage Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Statistically significant association between genotype at 7p12.2 (IKZF1), 10q21.2 (ARID5B) and the NBS associated locus, 8q21.3 (NBN) and ALL risk was found; odds ratios (ORs), 1.34 (P=0.002), 1.33 (P=0.003), and 1325.21 (P=0.0028), respectively.
|
21889209 |
2011 |
|
Childhood B Acute Lymphoblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia.
|
20460642 |
2010 |
|
Precursor B-cell lymphoblastic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also confirmed a selective effect for B-cell acute lymphoblastic leukemia with hyperdiploidy and report a putative gender-specific effect of ARID5B SNPs on acute lymphoblastic leukemia risk in males.
|
20460642 |
2010 |
|
Childhood Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
It was found that the variants rs10740055 of ARID5B and rs6964823 of IKZF1 act individually and additively as risk factors in the development of leukemia in the populations of Jammu and Kashmir in Northern India.
|
30810385 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The functional polymorphisms of ARID5B and IKZF1 are associated with acute myeloid leukemia risk in a Han Chinese population.
|
29292192 |
2018 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
One transcript near the ARID5B gene locus was specifically expressed in TAL1-positive T-ALL cases.
|
29654272 |
2018 |
|
Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, the authors examine CD14+ blood monocyte's transcriptome and epigenome signatures to find differential methylation and expression of ARID5B to be associated with human atherosclerosis.
|
28855511 |
2017 |
|
Atherosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, the authors examine CD14+ blood monocyte's transcriptome and epigenome signatures to find differential methylation and expression of ARID5B to be associated with human atherosclerosis.
|
28855511 |
2017 |
|
Coronary Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Four single nucleotide polymorphisms (SNPs) in the modulator recognition factor 2/AT-rich interaction domain 5B (MRF2/ARID5B) gene located at chromosome 10q21.2 have been shown to be associated with both type 2 diabetes mellitus (T2DM) and coronary artery disease in a Japanese cohort.
|
28469100 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The present results identified MRF2/ARID5B as a potential susceptibility gene for new-onset T2DM in a Northern Chinese population, while the rs7087507 SNP was associated with HDL-C levels.
|
28469100 |
2017 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
ARID5B also activates the expression of the oncogene <i>MYC</i> Importantly, ARID5B is required for the survival and growth of T-ALL cells<i>,</i> and forced expression of ARID5B in immature thymocytes results in thymus retention, differentiation arrest, radioresistance, and tumor formation in zebrafish.
|
29326336 |
2017 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that ARID5B reinforces the oncogenic transcriptional program by positively regulating the TAL1-induced regulatory circuit and <i>MYC</i> in T-ALL, thereby contributing to T-cell leukemogenesis.
|
29326336 |
2017 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Recent genome-wide association studies (GWAS) focusing on pediatric acute lymphoblastic leukemia (ALL), the most common malignancy in children younger than 15 years old, have found evidence that single-nucleotide polymorphisms (SNPs) in IKZF1 (7p12.2), ARID5B (10q21.2), CDKN2A (9p21.3), and CEBPE (14q11.2) are strongly associated to the risk of developing pediatric ALL.
|
27184773 |
2016 |