|
Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
MonoSeq analysis identified several previously unreported mutations, including a novel hotspot in an A7 run in the terminal exon of ARID5B.The ARID5B indel mutations were seen in both MMR-deficient and MMR-normal tumors, suggesting biologic selection.
|
27346418 |
2016 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Recent genome-wide association studies (GWAS) focusing on pediatric acute lymphoblastic leukemia (ALL), the most common malignancy in children younger than 15 years old, have found evidence that single-nucleotide polymorphisms (SNPs) in IKZF1 (7p12.2), ARID5B (10q21.2), CDKN2A (9p21.3), and CEBPE (14q11.2) are strongly associated to the risk of developing pediatric ALL.
|
27184773 |
2016 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay.
|
24564228 |
2014 |
|
Childhood Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia.
|
24564228 |
2014 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Recent genome-wide association studies (GWAS) that focus on childhood acute lymphoblastic leukemia (ALL), the most common malignancy in children younger than 15 years old, have found evidence that single nucleotide polymorphisms (SNPs) in IKZF1 (7p12.2), ARID5B (10q21.2) and CEBPE (14q11.2) are strongly related to the risk of childhood ALL.
|
23608171 |
2013 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Recent genome-wide association studies (GWAS) that focus on childhood acute lymphoblastic leukemia (ALL), the most common malignancy in children younger than 15 years old, have found evidence that single nucleotide polymorphisms (SNPs) in IKZF1 (7p12.2), ARID5B (10q21.2) and CEBPE (14q11.2) are strongly related to the risk of childhood ALL.
|
23608171 |
2013 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Modulator recognition factor-2 (Mrf2/AT-rich interaction domain (Arid)5b) has been revealed to be involved in pathogenesis of atherosclerosis and adipogenesis.
|
22971728 |
2012 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Modulator recognition factor-2 (Mrf2/AT-rich interaction domain (Arid)5b) has been revealed to be involved in pathogenesis of atherosclerosis and adipogenesis.
|
22971728 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, polymorphisms on the MRF2/ARID5B gene were associated with susceptibility to T2D as well as adiponectin and other clinical factors, which was in a completely concordant way with their associations with CAD.
|
22971728 |
2012 |
|
Coronary Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population.
|
18612189 |
2008 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Four single nucleotide polymorphisms (SNPs) in the modulator recognition factor 2/AT-rich interaction domain 5B (MRF2/ARID5B) gene located at chromosome 10q21.2 have been shown to be associated with both type 2 diabetes mellitus (T2DM) and coronary artery disease in a Japanese cohort.
|
28469100 |
2017 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, polymorphisms on the MRF2/ARID5B gene were associated with susceptibility to T2D as well as adiponectin and other clinical factors, which was in a completely concordant way with their associations with CAD.
|
22971728 |
2012 |
|
Coronary Artery Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The results implicate possible disease relevance of the polymorphisms in the Mrf-2 gene with susceptibility to CAD.
|
18612189 |
2008 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Seven SNPs (rs10821936, rs10994982, rs7089424, rs2393732, rs2393782, rs2893881, rs4948488) of ARID5B were analyzed in 384 controls and 298 ALL children using genomic DNA and TaqMan probes.
|
31227872 |
2019 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate ARID5B<sup>low</sup> expression, particularly ARID5B<sup>low</sup>PHF2<sup>low</sup> expression, is linked to Ikaros dysfunction and involved in the oncogenic effect of high-risk ALL, which may represent a high-risk subgroup of ALL.
|
30420689 |
2018 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay.
|
24564228 |
2014 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Association was also validated at four known ALL susceptibility loci: ARID5B, IKZF1, CEBPE, and CDKN2A/2B.
|
23512250 |
2013 |
|
Hyperdiploid B Acute Lymphoblastic Leukemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the two ARID5B SNPs are associated with the risk of B-hyperdiploid ALL, which had a better therapeutic response than other ALL subtypes.
|
31274788 |
2019 |
|
Hyperdiploid B Acute Lymphoblastic Leukemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These SNPs are located at CDKN2A (rs3731217) and IKZF1 (rs4132601), genes frequently lost in ALL, and at CEBPE (rs2239633), ARID5B (rs7089424), PIP4K2A (rs10764338), and GATA3 (rs3824662), genes located on chromosomes gained in high-hyperdiploid ALL.
|
26575185 |
2015 |
|
Hyperdiploid B Acute Lymphoblastic Leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Consistent with findings in non-Hispanic White population, our study showed that variants within IKZF1, ARID5B, and CEBPE were associated with increased ALL risk, and the effects for ARID5B and CEBPE were most prominent in the high-hyperdiploid ALL subtype in the California Hispanic population.
|
25761407 |
2015 |
|
Hyperdiploid B Acute Lymphoblastic Leukemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
With logistic regression, we identified 6 SNPs in the ARID5B and IKZF1 genes associated with increased risk to B-cell ALL, and two SNPs in the STAT3 gene, which decreased the risk to hyperdiploid ALL.
|
23021489 |
2012 |
|
Hyperdiploid B Acute Lymphoblastic Leukemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs in ARID5B not only differed between ALL and non-ALL groups (rs10821936, P = 1.4 x 10(-15), odds ratio (OR) = 1.91; rs10994982, P = 5.7 x 10(-9), OR = 1.62) but also distinguished B-hyperdiploid ALL from other subtypes (rs10821936, P = 1.62 x 10(-5), OR = 2.17; rs10994982, P = 0.003, OR 1.72).
|
19684603 |
2009 |
|
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Blood urea nitrogen measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |