|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
|
29273807 |
2018 |
|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
|
26414677 |
2015 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Genetic and pharmacologic modulation of IRE1α and PERK in cultured cells, xenograft, and spontaneous genetic (RIP-Tag2) mouse models of PanNETs revealed that UPR signaling was optimized for adaptation and that inhibiting either IRE1α or PERK led to hyperactivation and apoptotic signaling through the reciprocal arm, thereby halting tumor growth and survival.
|
31672843 |
2019 |
|
Diabetes, Autoimmune
|
0.050 |
Biomarker
|
disease |
BEFREE |
We showed that ppins antigens excluded from expression in the endoplasmic reticulum (ER) did not induce CD8<sup>+</sup> T cells or autoimmune diabetes in RIP-B7.1 tg mice, but efficiently suppressed spontaneous diabetes development in NOD mice as well as ppins-induced CD8<sup>+</sup> T cell-mediated autoimmune diabetes in <i>PD-L1</i><sup>-/-</sup> mice.
|
30623001 |
2019 |
|
Diabetes, Autoimmune
|
0.050 |
Biomarker
|
disease |
BEFREE |
HLA-DR3-DQ2<sup>+</sup>huCD4<sup>+</sup>IA/IE<sup>-/-</sup>RIP.B7.1<sup>+</sup> mice spontaneously developed autoimmune diabetes (incidence 46% by 35 weeks of age), accompanied by numerous hallmarks of human type 1 diabetes (autoantibodies against GAD65 and proinsulin; pancreatic islet infiltration by CD4<sup>+</sup>, CD8<sup>+</sup> B220<sup>+</sup>, CD11b<sup>+</sup> and CD11c<sup>+</sup> immune cells).
|
31612266 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
These actions were examined in RIP-Tag2 transgenic mice with pancreatic neuroendocrine tumors that developed spontaneously and progressed as in humans. mpJX-594 initially infected tumor vascular endothelial cells, leading to vascular pruning and prolonged leakage in tumors but not in normal organs; parallel effects were observed in U87 gliomas.
|
29259007 |
2018 |
|
Diabetes, Autoimmune
|
0.050 |
Biomarker
|
disease |
BEFREE |
Pancreatic delivery of dsAAV8-RIP-XIAP prevented autoimmune diabetes in 70% of non-obese diabetic (NOD) mice, associated with decreased insulitis.
|
29883690 |
2018 |
|
Diabetes, Autoimmune
|
0.050 |
Biomarker
|
disease |
BEFREE |
Further, p75NTR activation of pDCs delayed the onset of autoimmune diabetes in RIP-CD80GP mice and aggravated graft-versus-host disease in a xenotransplantation model.
|
28861085 |
2017 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
In LLC, VEGF expression was largely restricted to pericytes and PDGF was largely restricted to endothelial cells, but, in RIP-Tag2 tumors, expression of both growth factors was more widespread and significantly greater than in LLC.
|
19401451 |
2009 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Intravenous injection of A-5-RIP-lacZ reporter gene constructs was used for evaluation of Ad-RIP-gene expression in tumors and other tissues.
|
17512546 |
2007 |
|
Diabetes, Autoimmune
|
0.050 |
Biomarker
|
disease |
BEFREE |
The diabetogenic, insulin-specific CD8 T cell response primed in the experimental autoimmune diabetes model in RIP-B7.1 mice.
|
17615584 |
2007 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
To determine whether we could accelerate the rate of islet amyloid formation, we crossbred our hIAPP transgenic animals with RIP-Tag mice that develop islet tumors and die at 12 wk of age from hypoglycemia.
|
14613923 |
2004 |
|
Diabetes
|
0.040 |
Biomarker
|
disease |
BEFREE |
Data from the LEW1.WR1 rat model of virus-induced disease and the RIP-B7.1 mouse model of diabetes suggest that innate immune signaling plays a key role in triggering disease progression.
|
28956297 |
2017 |
|
Diabetes Mellitus
|
0.040 |
Biomarker
|
group |
BEFREE |
Data from the LEW1.WR1 rat model of virus-induced disease and the RIP-B7.1 mouse model of diabetes suggest that innate immune signaling plays a key role in triggering disease progression.
|
28956297 |
2017 |
|
Diabetes
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
However, A-5-RIP-TK/GCV gene therapy caused diabetes associated with islet cell apoptosis, increased delta-cells and reduced pancreatic polypeptide (PP)-cell numbers.
|
17512546 |
2007 |
|
Diabetes
|
0.040 |
Biomarker
|
disease |
BEFREE |
The RIP-B7.1 model hence represents an attractive model for the characterization of cellular and molecular events involved in the CD8 T cell-mediated immune pathogenesis of diabetes.
|
17615584 |
2007 |
|
Diabetes Mellitus
|
0.040 |
GeneticVariation
|
group |
BEFREE |
However, A-5-RIP-TK/GCV gene therapy caused diabetes associated with islet cell apoptosis, increased delta-cells and reduced pancreatic polypeptide (PP)-cell numbers.
|
17512546 |
2007 |
|
Diabetes Mellitus
|
0.040 |
Biomarker
|
group |
BEFREE |
The RIP-B7.1 model hence represents an attractive model for the characterization of cellular and molecular events involved in the CD8 T cell-mediated immune pathogenesis of diabetes.
|
17615584 |
2007 |
|
Diabetes
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Surprisingly, we found that even in the absence of HLA-DQ8 and CD4 T cells, a substantial fraction of the RIP-B7.1mII(-/-) mice developed diabetes.
|
15240665 |
2004 |
|
Diabetes Mellitus
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Surprisingly, we found that even in the absence of HLA-DQ8 and CD4 T cells, a substantial fraction of the RIP-B7.1mII(-/-) mice developed diabetes.
|
15240665 |
2004 |
|
Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Furthermore, their interaction and functions in regulating the development of osteosarcoma were clarified by Western blot and RIP assay.
|
31044561 |
2019 |
|
Osteosarcoma of bone
|
0.030 |
Biomarker
|
disease |
BEFREE |
Furthermore, their interaction and functions in regulating the development of osteosarcoma were clarified by Western blot and RIP assay.
|
31044561 |
2019 |
|
Childhood Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Furthermore, their interaction and functions in regulating the development of osteosarcoma were clarified by Western blot and RIP assay.
|
31044561 |
2019 |