RPAIN, RPA interacting protein, 84268

N. diseases: 60; N. variants: 8
Disease: Diabetes ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 Biomarker disease BEFREE Data from the LEW1.WR1 rat model of virus-induced disease and the RIP-B7.1 mouse model of diabetes suggest that innate immune signaling plays a key role in triggering disease progression. 28956297 2017
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 GeneticVariation disease BEFREE However, A-5-RIP-TK/GCV gene therapy caused diabetes associated with islet cell apoptosis, increased delta-cells and reduced pancreatic polypeptide (PP)-cell numbers. 17512546 2007
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 Biomarker disease BEFREE The RIP-B7.1 model hence represents an attractive model for the characterization of cellular and molecular events involved in the CD8 T cell-mediated immune pathogenesis of diabetes. 17615584 2007
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 GeneticVariation disease BEFREE Surprisingly, we found that even in the absence of HLA-DQ8 and CD4 T cells, a substantial fraction of the RIP-B7.1mII(-/-) mice developed diabetes. 15240665 2004