RPAIN, RPA interacting protein, 84268

N. diseases: 60; N. variants: 8
Disease: Diabetes, Autoimmune ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0205734
Disease: Diabetes, Autoimmune
Diabetes, Autoimmune 		0.050 Biomarker disease BEFREE We showed that ppins antigens excluded from expression in the endoplasmic reticulum (ER) did not induce CD8<sup>+</sup> T cells or autoimmune diabetes in RIP-B7.1 tg mice, but efficiently suppressed spontaneous diabetes development in NOD mice as well as ppins-induced CD8<sup>+</sup> T cell-mediated autoimmune diabetes in <i>PD-L1</i><sup>-/-</sup> mice. 30623001 2019
CUI: C0205734
Disease: Diabetes, Autoimmune
Diabetes, Autoimmune 		0.050 Biomarker disease BEFREE HLA-DR3-DQ2<sup>+</sup>huCD4<sup>+</sup>IA/IE<sup>-/-</sup>RIP.B7.1<sup>+</sup> mice spontaneously developed autoimmune diabetes (incidence 46% by 35 weeks of age), accompanied by numerous hallmarks of human type 1 diabetes (autoantibodies against GAD65 and proinsulin; pancreatic islet infiltration by CD4<sup>+</sup>, CD8<sup>+</sup> B220<sup>+</sup>, CD11b<sup>+</sup> and CD11c<sup>+</sup> immune cells). 31612266 2019
CUI: C0205734
Disease: Diabetes, Autoimmune
Diabetes, Autoimmune 		0.050 Biomarker disease BEFREE Pancreatic delivery of dsAAV8-RIP-XIAP prevented autoimmune diabetes in 70% of non-obese diabetic (NOD) mice, associated with decreased insulitis. 29883690 2018
CUI: C0205734
Disease: Diabetes, Autoimmune
Diabetes, Autoimmune 		0.050 Biomarker disease BEFREE Further, p75NTR activation of pDCs delayed the onset of autoimmune diabetes in RIP-CD80GP mice and aggravated graft-versus-host disease in a xenotransplantation model. 28861085 2017
CUI: C0205734
Disease: Diabetes, Autoimmune
Diabetes, Autoimmune 		0.050 Biomarker disease BEFREE The diabetogenic, insulin-specific CD8 T cell response primed in the experimental autoimmune diabetes model in RIP-B7.1 mice. 17615584 2007