Disease: Hypercholesterolemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia 		0.030 Biomarker disease BEFREE Strategies to increase FGF19 signaling to activate SHP might be developed for treatment of hypercholesterolemia. 30521806 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia 		0.030 Biomarker disease BEFREE Appraisal of the liver revealed an up-regulation of mRNA expressions of the small heterodimer partner (Shp) and attenuation of Cyp7a1, which contributed to hypercholesterolemia in vitamin D-deficiency. 29243851 2018
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia 		0.030 AlteredExpression disease BEFREE In Fxr(-/-) and wild-type mice with hypercholesterolemia, injection of 1,25(OH)2D3 consistently reduced levels of plasma and liver cholesterol and Shp mRNA, and increased hepatic Cyp7a1 mRNA and protein; these changes were not observed in Shp(-/-) mice given 1,25(OH)2D3 and fed Western diets. 24365583 2014