|
Mucoepidermoid Carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
|
12539049 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.
|
14720503 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ISH analysis performed in cytogenetic suspension and/or in tumor paraffin sections demonstrated MAML2 rearrangement in 7 of 10 cases of MEC: all five cases with t(11;19), one case with normal karyotype, and one unkaryotyped case.
|
15269296 |
2004 |
|
Mucoepidermoid Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analyses of the Notch target genes HES5 and MASH1 in MEC tumors with and without the WAMTP1-MAML2 fusion revealed upregulation of HES5 and downregulation of MASH1 in fusion positive MECs compared to normal salivary gland tissue and MECs lacking the fusion.
|
14720503 |
2004 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have demonstrated that ISH and RT-PCR are sensitive methods for detecting MECT1-MAML2 in MEC.
|
15269296 |
2004 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Analyses of the Notch target genes HES5 and MASH1 in MEC tumors with and without the WAMTP1-MAML2 fusion revealed upregulation of HES5 and downregulation of MASH1 in fusion positive MECs compared to normal salivary gland tissue and MECs lacking the fusion.
|
14720503 |
2004 |
|
Adenolymphoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Neither the t(11;19) nor MECT1-MAML2 was detected in any case of WT, nor in control samples from polymorphous low-grade adenocarcinoma, acinic cell carcinoma, or normal parotid gland tissue.
|
15269296 |
2004 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.
|
15729701 |
2005 |
|
Eccrine acrospiroma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
RT-PCR analysis of a clear cell hidradenoma with a t(11;19)(q21;p13) translocation revealed expression of a TORC1-MAML2 fusion transcript consisting of exon 1 of TORC1 fused to exons 2-5 of MAML2.
|
15729701 |
2005 |
|
Clear cell hidradenoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
RT-PCR analysis of a clear cell hidradenoma with a t(11;19)(q21;p13) translocation revealed expression of a TORC1-MAML2 fusion transcript consisting of exon 1 of TORC1 fused to exons 2-5 of MAML2.
|
15729701 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A t(11;19) and/or an MECT1-MAML2 fusion was detected in more than 55% of the tumors.
|
16444749 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data show that the 'gain-of-function' activity from aberrant Mect1-Maml2 expression is a candidate therapeutic target for this group of malignant salivary gland tumors.
|
16652146 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The MECT1-MAML2 fusion transcript was detected in 27 of the 71 (38%) mucoepidermoid carcinoma cases but not in any case of nonmucoepidermoid carcinoma tumors.
|
16818685 |
2006 |
|
Mucoepidermoid Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The MECT1-MAML2 fusion transcript was detected in 27 of the 71 (38%) mucoepidermoid carcinoma cases but not in any case of nonmucoepidermoid carcinoma tumors.
|
16818685 |
2006 |
|
Mucoepidermoid Carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The MECT1-MAML2 fusion transcript was detected in 27 of the 71 (38%) mucoepidermoid carcinoma cases but not in any case of nonmucoepidermoid carcinoma tumors.
|
16818685 |
2006 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also generated a mutant Mect1-Maml2 expression plasmid that carried silent nucleotide changes within the RNAi target sequence and observed that co-transfection of this mutant, but not wild-type Mect1-Maml2, could partially rescue RNAi growth inhibition in the MEC tumor line.
|
16652146 |
2006 |
|
Mucoepidermoid Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Western blot and immunohistochemical studies demonstrated that the MECT1-MAML2 fusion protein was expressed in all MEC-specific cell types.
|
16444749 |
2006 |
|
Malignant neoplasm of salivary gland
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation.
|
16652146 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data concur with previously reported cases, in which t(11;19) appears to be the primary chromosomal aberration for pulmonary MEC in children, and that the MECT1-MAML2 fusion transcript is associated with a better prognosis in MEC tumors.
|
17618868 |
2007 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our findings thus demonstrate that the CRTC1-MAML2 gene fusion is frequent in hidradenomas and is associated with clear cell variants of this tumor.
|
17334997 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We analyzed 55 primary salivary gland tumors including 22 mucoepidermoid carcinomas (MECs) to determine the association of MECT1/TORC1/CRTC1-MAML2 fusion transcript to tumor types, level of MEC differentiation and clinicopathologic parameters.
|
17437281 |
2007 |
|
Mucoepidermoid Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data concur with previously reported cases, in which t(11;19) appears to be the primary chromosomal aberration for pulmonary MEC in children, and that the MECT1-MAML2 fusion transcript is associated with a better prognosis in MEC tumors.
|
17618868 |
2007 |
|
Mucoepidermoid Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior.
|
17437281 |
2007 |
|
Mucoepidermoid Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specific chromosomal translocations are recognized in pleomorphic adenoma (with translocation involving PLGA1 or HMGA2 gene) and mucoepidermoid carcinoma (with MECT1-MAML2 gene fusion).
|
17539914 |
2007 |
|
Mucoepidermoid Carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior.
|
17437281 |
2007 |