|
Mucoepidermoid Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Examination of the CRTC1/3-MAML2 fusion gene showed no relation between SRCC of primary unknown with metastasis to the cervical lymph node and MEC of the parotid gland.
|
30954307 |
2020 |
|
Mucoepidermoid Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Salivary gland MEC are most frequently associated with CRTC1-MAML2 translocations.
|
30380176 |
2019 |
|
Mucoepidermoid Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Bronchial Mucoepidermoid Carcinoma With the Classic MAML2 Gene Rearrangement in a 2-year-old Boy.
|
28492094 |
2019 |
|
Mucoepidermoid Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Articles that assessed the association between the CRTC1-MAML2 translocation and survival of MEC patients were selected for the systematic review.
|
31661572 |
2019 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rearrangement of mastermind like transcriptional coactivator 2 (MAML2) (11q21) gene was shown to be present in tumor cells by fluorescence in situ hybridization, supporting the diagnosis of a low-grade Warthin-like mucoepidermoid carcinoma.
|
31177170 |
2019 |
|
Mucoepidermoid Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gefitinib represses JAK-STAT signaling activated by CRTC1-MAML2 fusion in mucoepidermoid carcinoma cells.
|
30605061 |
2019 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aims of this study were to determine the prognostic significance of MEC grading systems and MAML2 rearrangement status.
|
31021855 |
2019 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CRTC1-MAML2 fusion is often detected in low- or intermediate-grade salivary mucoepidermoid carcinoma (MEC), and it is associated with a favorable clinical course.
|
31351495 |
2019 |
|
Mucoepidermoid Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We present 2 variants of MEC for which MAML2 studies were crucial in establishing a diagnosis: a previously undescribed ciliated variant, and the recently described Warthin-like variant.
|
28877061 |
2018 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CRTC1/3-MAML2 fusion gene is a characteristic molecular feature of MEC of the salivary gland.
|
30138216 |
2018 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor categories as described by the World Health Organization reflect, in part, a true genetic heterogeneity (e.g., translocations involving CRTC1 and CRTC3-MAML2 genes in mucoepidermoid carcinoma and MYB-NFIB fusion in adenoid cystic carcinoma).
|
28930752 |
2018 |
|
Mucoepidermoid Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The CRTC1-MAML2 fusion gene resulting from a t(11;19)(q21;p13) translocation, is now known to be a feature of both low-grade and high-grade mucoepidermoid carcinomas associated with improved survival.
|
29076877 |
2018 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that LINC00473 transcription was significantly induced in human CRTC1-MAML2-positive MEC cell lines and primary MEC tumors, and was tightly correlated with the CRTC1-MAML2 RNA level.
|
29353885 |
2018 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of MAML2 rearrangement can be used as a supportive evidence to distinguish central MEC from GOC.
|
29131467 |
2018 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study reports a case of MEC harboring a mastermind-like transcriptional coactivator 2 (<i>MAML2</i>) gene translocation in the sublingual gland.
|
28927048 |
2017 |
|
Mucoepidermoid Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Through these integrated genomic analyses, MECT1-MAML2 translocation and somatic TP53 and POU6F2 mutations appear to be the main drivers of MEC.
|
27340278 |
2017 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using MAML2 fluorescence in situ hybridization (FISH), a total of 49 MEC cases were separated into MAML2 fusion-positive (32 cases) and MAML2 fusion-negative groups (17 cases).
|
27769871 |
2017 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An oncogenic CRTC1- or CRTC3-MAML2 gene fusion has been identified in a number of MECs.
|
28438292 |
2017 |
|
Mucoepidermoid Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, reverse-transcription polymerase chain reaction revealed the CRTC3-MAML2 fusion gene product diagnostic of MEC.
|
28412212 |
2017 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fluorescence in situ hybridization for the MECT1/MAML2 fusion gene frequently associated with MEC was performed and was negative.
|
28006088 |
2017 |
|
Mucoepidermoid Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first report of CRTC1-MAML2 fusion gene detection in a clear cell variant of MEC.
|
26297211 |
2017 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hence, gene rearrangements such as CRTC1-MAML2 in mucoepidermoid carcinomas have shown excellent specificity, and more than that, it has been strongly correlated with low-grade tumors and consequently with an increased survival rate and better prognosis of patients affected by neoplasms carrying this translocation.
|
25990369 |
2016 |
|
Mucoepidermoid Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although the incidence of this fusion in mucoepidermoid carcinoma varies, it is generally accepted that more than 50% of this entity manifest the CRTC1-MAML2.
|
26316332 |
2016 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to adults, MECT1/MAML2 fusion transcripts occur with a frequency of 100% in our pediatric MEC series.
|
26221861 |
2016 |
|
Mucoepidermoid Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amphiregulin (AREG), an epidermal growth factor receptor (EGFR) ligand, has been shown to be a downstream target of CRTC1-MAML2 fusion, and to play a role in tumor growth and survival in CRTC1-MAML2-positive MEC cell lines.
|
27393417 |
2016 |