KDM2B, lysine demethylase 2B, 84678

N. diseases: 86; N. variants: 6
Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis. 31471323 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE Moreover, FBXL10 depletion in DLBCL cells abrogates tumor growth in mouse xenograft models. 29352142 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE It has recently been shown that KDM2B co-operates with Polycomb Group proteins to promote cell migration and angiogenesis in tumors. 29408056 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 GeneticVariation group BEFREE As such, the mammalian lysine-specific demethylase 2 (KDM2) homologs, KDM2A and KDM2B, are either oncogenic or tumor suppressive depending on specific pathological contexts. 30233643 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE KDM2B-silenced tumors exhibited slower growth in vivo. 28661478 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 AlteredExpression group BEFREE In a xenograft model, the downregulation of KDM2B can inhibit tumour growth. 28506929 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 AlteredExpression group BEFREE In addition, in tumors lacking the controller function of p53, a lower expression of JHDM1B is associated with an increased tumor size at diagnosis. 25273595 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE After the intravenous injection of APTEDB-TCL-SPION into the NDY-1 mouse tumor xenograft model, a significant decrease in the signal within the tumor was observed in the T2*-weighted images; however, there was only a marginal change in the signal of non-targeting SPIONs such as APTscramble-TCL-SPION or TCL-SPION. 24955145 2014