|
Chronic granulomatous disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Chronic granulomatous disease (CGD) is a rare genetic disorder of neutrophil activity, resulting in increased rate of recurrent infections with catalase-positive bacteria and fungi, as well as various autoimmune diseases such as sarcoidosis, rheumatoid arthritis, and discoid and/or systemic lupus erythematosus.
|
31522454 |
2019 |
|
Chronic granulomatous disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Infections with specific catalase positive organisms, especially <i>Burkholderia cepacia, Serratia, Nocardia</i> and <i>Chromobacterium violaceum</i> prompt a workup for CGD in affected patients.
|
30984725 |
2019 |
|
Chronic granulomatous disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Patients with CGD are at increased risk of life-threatening infections with catalase-positive bacteria and fungi and inflammatory complications such as CGD colitis.
|
29168144 |
2017 |
|
Chronic granulomatous disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Chronic granulomatous disease (CGD) is an inherited phagocytic disorder characterized by recurrent infections with usually catalase-positive organisms.
|
28332028 |
2017 |
|
Chronic granulomatous disease
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest an unrecognized and unanticipated susceptibility to weakly pathogenic Actinomyces species in patients with CGD because these are catalase-negative organisms previously thought to be nonpathogenic in CGD.
|
19874205 |
2009 |
|
Chronic granulomatous disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CGD usually presents in early childhood with recurrent or severe infection with catalase-positive bacteria and fungi.
|
18625437 |
2008 |
|
Chronic granulomatous disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Five genetic types of chronic granulomatous disease have been described and in each case the clinical manifestations relate to the inability to effectively kill catalase-positive organisms.
|
12498808 |
2002 |
|
Chronic granulomatous disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Five male patients from four different families presented with a clinical record of chronic granulomatous disease (CGD): recurrent infections of the skin and/or respiratory tract with catalase-positive microorganisms, sometimes in combination with granulomata and/or abscesses in various organs.
|
1431553 |
1992 |
|
Chronic granulomatous disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The organism described in this report is an addition to the growing list of catalase-positive organisms which can potentially cause severe morbidity in patients with chronic granulomatous disease.
|
2380349 |
1990 |
|
Chronic granulomatous disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Effective inhibition by normal alpha 1-antitrypsin occurred at much lower concentrations when azide or catalase was added, or when normal neutrophils were replaced by those from a donor with chronic granulomatous disease.
|
6151045 |
1984 |
|
Chronic granulomatous disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Chronic granulomatous disease represents a group of disorders of phagocytic cell oxidative metabolism involving recurrent infections with catalase-positive microorganisms and chronic inflammation.
|
6227266 |
1983 |
|
Chronic granulomatous disease
|
0.100 |
Biomarker
|
group |
BEFREE |
PMN from patients with CGD killed increasing numbers of catalase-negative S. faecalis with normal efficiency, reaching a mean of 14 S. faecalis killed per cell at 100:1.
|
408453 |
1977 |