|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The major growth in point-of-care malaria diagnosis over the past decade has been based on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect Plasmodium falciparum via its abundant histidine-rich protein 2 (HRP2).
|
31848119 |
2020 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accurate malaria diagnosis is foundational for control and elimination, and Haiti relies on HRP2-based rapid diagnostic tests (RDTs) identifying Plasmodium falciparum in clinical and community settings.
|
31630194 |
2020 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Malaria rapid diagnostic tests (RDTs) primarily detect <i>Plasmodium falciparum</i> antigen histidine-rich protein 2 (HRP2) and the malaria-conserved antigen lactate dehydrogenase (LDH) for <i>P. vivax</i> and other malaria species.
|
30404944 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
CareStart™ malaria HRP2/pLDH (Pf/pan) had high sensitivity and strong agreement with microscopy results.
|
31690321 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Malaria rapid diagnostic tests (mRDTs) that target histidine-rich protein 2 (HRP2) are important tools for Plasmodium falciparum diagnosis.
|
31249999 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
If T1-HRP2 was positive the malaria diagnosis was considered as "inconclusive" and microscopy was performed.
|
30759130 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
In endemic areas, the diagnoses of malaria and hepatitis B among pregnant women on antenatal visits are done using histidine-rich protein 2 (HRP2) and hepatitis B surface antigen (HBsAg) rapid diagnostic tests (RDTs), respectively, which are, however, reported to give some false positive results.
|
30726218 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hrp2/hrp3 deletions are increasingly reported from all malaria endemic regions but are currently only identified by laborious methodologies.
|
31761619 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The HRP2/pLDH(Pf) based RDT yet demonstrate to be an effective tool for malaria surveillance program.
|
30138695 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on results of HRP2-RDT screening, the children were grouped into one of the following three categories: (1) tested positive for malaria using RDT and received anti-malarial treatment (group 1, n = 85); (2) tested negative for malaria using RDT and were given anti-malarial treatment by the admitting physician (group 2, n = 74); or, (3) tested negative for malaria using RDT and did not receive any anti-malarial treatment (group 3, n = 101).
|
30547795 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
An aptamer for specific detection of falciparum malaria holds promise as a new strategy for species-specific malaria diagnosis rather than the conventional HRP2 immuno-assay.
|
29080831 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
RBC-D correlated inversely with parasitemia and lactate in knowlesi malaria and HRP2 in falciparum malaria, and it correlated with hemoglobin nadir in knowlesi malaria.
|
29487058 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Malaria infection was assessed using an histidine-rich protein 2 (HRP2) rapid diagnostic test at admission and at any follow-up visit with fever.
|
29522089 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finger-prick capillary blood was tested with First Response<sup>®</sup> Malaria Ag P. falciparum (HRP2).
|
29471833 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Venous blood samples were obtained by trained personnel and samples were screened for malaria using CareStart and SD Bioline HRP2 and HRP2 with pLDH based RDTs with blood slides for malaria microscopy as "gold standard".
|
30192839 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The histidine-rich protein-2 (HRP2) specific to <i>Plasmodium falciparum</i> was absent in 100% of examined samples, while aldolase, common to the four types of plasmodial pathogens causing human malaria, was detected in 56% of individuals with no significant difference between the two tested social groups: high officials (HO) and workers (W).
|
30151391 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent conflicting reports call into question whether α-HRP2 antibodies are present in human host circulation and if resulting immune complexes could interfere with HRP2 detection on malaria RDTs.
|
29986725 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
An HRP2-based ultrasensitive RDT (uRDT) developed to improve the detection of low-density infections was evaluated during prevalence surveys within a malaria elimination program in a low-transmission area of eastern Myanmar.
|
29898998 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deletions of the Plasmodium falciparum hrp2 and hrp3 genes can affect the performance of HRP2-based malaria rapid diagnostic tests (RDTs).
|
29116127 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
HRP2 antigen bands demonstrated poor specificity for the diagnosis of malaria compared to that of real-time PCR in a high-transmission setting.
|
28275077 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of CareStart™ Malaria HRP2/pLDH (Pf/pan) Combo Test in a malaria low transmission region of Senegal.
|
28797261 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
A positive dual-antigen (HRP2/pLDH) RDT has higher sensitivity than the use of clinical manifestations to detect severe malaria, making it a promising tool in the triage of children with malaria in low-resource settings.
|
29020298 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most malaria testing is by rapid diagnostic tests (RDTs) that detect <i>Plasmodium falciparum</i> histidine-rich protein 2 (HRP2).
|
28722629 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Malaria occurrence was tested using rapid diagnostic test kit (CareStart HRP-2 Pf).
|
28623926 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of histidine-rich protein 2 (HRP2) from the malaria parasite Plasmodium falciparum provides evidence for active or recent infection, and is utilized for both diagnostic and surveillance purposes, but current laboratory immunoassays for HRP2 are hindered by low sensitivities and high costs.
|
28192523 |
2017 |