IL17RC, interleukin 17 receptor C, 84818

N. diseases: 65; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4225324
Disease: CANDIDIASIS, FAMILIAL, 9
CANDIDIASIS, FAMILIAL, 9 		0.600 Biomarker disease GENOMICS_ENGLAND Chronic mucocutaneous candidiasis: what can we conclude about IL-17 antagonism? 29076381 2018
CUI: C4225324
Disease: CANDIDIASIS, FAMILIAL, 9
CANDIDIASIS, FAMILIAL, 9 		0.600 CausalMutation disease CLINVAR
CUI: C4225324
Disease: CANDIDIASIS, FAMILIAL, 9
CANDIDIASIS, FAMILIAL, 9 		0.600 Biomarker disease CTD_human
CUI: C0006845
Disease: Candidiasis, Chronic Mucocutaneous
Candidiasis, Chronic Mucocutaneous 		0.510 Biomarker disease GENOMICS_ENGLAND Chronic mucocutaneous candidiasis: what can we conclude about IL-17 antagonism? 29076381 2018
CUI: C0006845
Disease: Candidiasis, Chronic Mucocutaneous
Candidiasis, Chronic Mucocutaneous 		0.510 Biomarker disease BEFREE Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. 25918342 2015
CUI: C0006845
Disease: Candidiasis, Chronic Mucocutaneous
Candidiasis, Chronic Mucocutaneous 		0.510 GermlineCausalMutation disease ORPHANET Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. 25918342 2015
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.330 Biomarker disease CTD_human These observations provide evidence that IL-17RC protein isoforms are differentially expressed in prostatic cells and cancer tissues and may play a negative or positive role in the initiation and progression of prostate cancer. 17603628 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.330 AlteredExpression disease BEFREE Furthermore, immunohistochemical staining of prostate tissue microarrays showed that IL-17RC protein expression was significantly higher in androgen-independent prostate cancers than in androgen-dependent ones when anti-ICD was used, whereas the trend was reversed using anti-ECD. 17603628 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.330 Biomarker disease BEFREE Thus, IL-17RL is a potential therapeutic target in the treatment of prostate cancer. 16397230 2006
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.330 AlteredExpression disease BEFREE Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. 11706037 2002
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.310 Biomarker group CTD_human Differential expression of IL-17RC isoforms in androgen-dependent and androgen-independent prostate cancers. 17603628 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.310 AlteredExpression group BEFREE In an in vivo model of human prostate tumor growth in nude mice (CWR22 xenograft model), IL-17RL expression in tumors was induced by androgen deprivation. 16397230 2006
CUI: C0340803
Disease: Capillary malformation (disorder)
Capillary malformation (disorder) 		0.300 Biomarker disease GENOMICS_ENGLAND There were no reports of cancer in 31 patients with CMC caused by an isolated IL-17 deficiency (IL-17F, IL-17RA, IL17RC); however, a study would need over 1000 patients to detect even a 10-fold increase in the most common malignancy of CMC patients. 29076381 2018
CUI: C0007971
Disease: Cheilitis
Cheilitis 		0.100 Biomarker disease HPO
CUI: C0010200
Disease: Coughing
Coughing 		0.100 Biomarker phenotype HPO
CUI: C0015230
Disease: Exanthema
Exanthema 		0.100 Biomarker phenotype HPO
CUI: C0018965
Disease: Hematuria
Hematuria 		0.100 Biomarker phenotype HPO
CUI: C0019079
Disease: Hemoptysis
Hemoptysis 		0.100 Biomarker phenotype HPO
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.100 Biomarker group HPO
CUI: C0033774
Disease: Pruritus
Pruritus 		0.100 Biomarker phenotype HPO
CUI: C0036572
Disease: Seizures
Seizures 		0.100 Biomarker phenotype HPO
CUI: C0037299
Disease: Skin Ulcer
Skin Ulcer 		0.100 Biomarker phenotype HPO
CUI: C0040261
Disease: Onychomycosis
Onychomycosis 		0.100 Biomarker disease HPO
CUI: C0041834
Disease: Erythema
Erythema 		0.100 Biomarker phenotype HPO
CUI: C0262655
Disease: Recurrent urinary tract infection
Recurrent urinary tract infection 		0.100 Biomarker disease HPO