|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrated significant association of RA with TIM-3 rs1036199 polymorphism under dominant (OR, 1.93, 95% CI, 1.43-2.61) and allelic models (OR, 1.74, 95% CI, 1.31-2.30).
|
30730912 |
2019 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Association of Tim-3 and PD-1 expression with disease activity of RA patients was also addressed.
|
29626269 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nevertheless, no correlation between TIM-3 level and an RA disease activity score of 28 was found.
|
30106887 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Transfection of Tim-3 siRNA significantly decreased Tim-3 expression in FLS from patients with RA.
|
28962218 |
2017 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cells from the RA joint expressed several T cell co-inhibitory receptors, including PD-1, TIM-3, and Tigit.
|
28791012 |
2017 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate a negative correlation between TIM-3 and the disease progression of RA.
|
24689929 |
2014 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased Tim-1 expression has been shown in mononuclear cells from systemic lupus erythematosus patients and Tim-3 may be involved in a protective role in rheumatoid arthritis.
|
23406933 |
2013 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
T cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3) has been established as a negative regulatory molecule and plays a critical role in inflammatory diseases such as rheumatoid arthritis, hepatitis B and C, and human immunodeficiency virus (HIV)-related inflammation.
|
23385979 |
2013 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TIM-3 mRNA expression was significantly lower in CD4+ T cells from RA patients compared with those in healthy controls (p = 0.028).
|
21717191 |
2012 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T-cell immunoglobulin and mucin domains 1 (TIM-1) and 3 (TIM-3) have been shown to be associated with susceptibility to rheumatoid arthritis (RA) in many ethnicities.
|
22353209 |
2012 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TIM3 genetic polymorphisms may have a role in the development of RA regardless of a shared epitope status.
|
21565238 |
2011 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that polymorphism of +4259 G>T in TIM-3 gene may be one of the most important genetic factors associated with the RA susceptibility among different populations, and genetic variations of TIM-3 gene contribute to RA susceptibility among different populations.
|
21989170 |
2011 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Many previous studies have demonstrated that TIM-3 influences chronic autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis.
|
19768575 |
2010 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
LHGDN |
In the present study, we analyzed the association of the genotype and allele frequencies between rheumatoid arthritis (RA) patients and the controls without RA using large samples size at the -1516G>T, -574T>G and 4259G>T polymorphic sites of human Tim-3 gene.
|
15325803 |
2004 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results strongly suggest that -574T>G and 4259G>T polymorphism of the Tim-3 might be associated with susceptibility to RA.
|
15325803 |
2004 |