We compared the long non-coding RNA levels in gastric cancer (GC) and para-cancerous tissues in the Gene Expression Omnibus, and found that small nucleolar RNA host gene 12 (<i>SNHG12</i>) was upregulated in GC tissues.
In conclusion, the present study demonstrates that inhibition of SNHG12 suppresses GC cell proliferation and migration by modulation of miR-16 expression, and thus suggests that the SNHG12/miR-16 interaction may be used as a promising target for GC treatment.
Survival analysis showed that highly expressed lncRNA SNHG12 in patients with gastric carcinoma was negatively correlated to the overall survival time.
In addition, the present study determined that miR‑320 was directly regulated by SNHG12 and suppression of miR‑320 expression reversed the inhibitory effects of SNHG12 siRNA on GC cell proliferation and invasion.