COPS3, COP9 signalosome subunit 3, 8533

N. diseases: 24; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0795864
Disease: Smith-Magenis syndrome
Smith-Magenis syndrome 		0.010 Biomarker disease BEFREE We assessed the potential effect of haploinsufficiency of SGN3 in SMS patient lymphoblastoid cell lines through transfection studies and western analysis. 10588842 1999
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 AlteredExpression disease BEFREE We present detailed analysis of TP53 mutations and MDM2 and COPS3 expression levels in a set of 23 OS. 12917637 2003
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 Biomarker disease BEFREE We conclude that PMP22 and COPS3, and possibly also the three ESTs, are candidate amplification targets in 17p11.2 approximately p12 in osteosarcoma. 15193436 2004
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.070 Biomarker disease BEFREE We conclude that PMP22 and COPS3, and possibly also the three ESTs, are candidate amplification targets in 17p11.2 approximately p12 in osteosarcoma. 15193436 2004
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 Biomarker disease BEFREE We conclude that PMP22 and COPS3, and possibly also the three ESTs, are candidate amplification targets in 17p11.2 approximately p12 in osteosarcoma. 15193436 2004
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 AlteredExpression disease BEFREE Overexpression of COPS3 has been linked to TP53 protein degradation and, being equivalent to TP53 mutation, the induction of genomic instability, which frequently occurs in high-grade osteosarcoma. 15325100 2004
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.070 AlteredExpression disease BEFREE Overexpression of COPS3 has been linked to TP53 protein degradation and, being equivalent to TP53 mutation, the induction of genomic instability, which frequently occurs in high-grade osteosarcoma. 15325100 2004
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 AlteredExpression disease BEFREE Overexpression of COPS3 has been linked to TP53 protein degradation and, being equivalent to TP53 mutation, the induction of genomic instability, which frequently occurs in high-grade osteosarcoma. 15325100 2004
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 Biomarker disease BEFREE Amplification of COPS3, detected in 31% of the osteosarcomas, was strongly associated with large tumor size (P=.0009), but was not associated with age at diagnosis, site, sex, and tumor necrosis. 17366602 2007
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.070 Biomarker disease BEFREE COPS3 may function as an oncogene in osteosarcoma, and an increased copy number may lead to an unfavorable prognosis. 17366602 2007
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 Biomarker disease BEFREE COPS3 may function as an oncogene in osteosarcoma, and an increased copy number may lead to an unfavorable prognosis. 17366602 2007
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.030 Biomarker phenotype BEFREE COPS3 amplification was significantly correlated with a shorter time to metastasis with an estimated hazard ratio (HR) of 1.61 (95% confidence interval [CI], 1.02-2.55) in univariate analysis (log-rank test, P=.042). 17366602 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE However, in an a priori multivariate Cox model including the other clinical parameters, the HR for COPS3 amplification decreased to 1.32 (95% CI, 0.82-2.13, P=.25), mainly due to the strong correlation with tumor size. 17366602 2007
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis 		0.010 Biomarker phenotype BEFREE Amplification of COPS3, detected in 31% of the osteosarcomas, was strongly associated with large tumor size (P=.0009), but was not associated with age at diagnosis, site, sex, and tumor necrosis. 17366602 2007
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 AlteredExpression disease BEFREE Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. 21436869 2011
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.070 AlteredExpression disease BEFREE Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. 21436869 2011
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 AlteredExpression disease BEFREE Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. 21436869 2011
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.030 AlteredExpression phenotype BEFREE Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. 21436869 2011
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 Biomarker disease BEFREE We conclude that these genes, including COPS3 and PMP22, are candidate oncogenes in 17p11.2-p12 of importance in osteosarcoma tumourigenesis. 22292074 2012
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.070 Biomarker disease BEFREE We conclude that these genes, including COPS3 and PMP22, are candidate oncogenes in 17p11.2-p12 of importance in osteosarcoma tumourigenesis. 22292074 2012
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 Biomarker disease BEFREE We conclude that these genes, including COPS3 and PMP22, are candidate oncogenes in 17p11.2-p12 of importance in osteosarcoma tumourigenesis. 22292074 2012
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 Biomarker disease BEFREE The COPS3 gene has stimulating effect on cell proliferation and progression of osteosarcomas and related cells. 22631635 2012
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.010 AlteredExpression disease BEFREE In this study, therefore, the effect of COPS3 silencing via COPS3 siRNA on lung cancer cell proliferation was examined. 22631635 2012
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.010 AlteredExpression disease BEFREE In this study, therefore, the effect of COPS3 silencing via COPS3 siRNA on lung cancer cell proliferation was examined. 22631635 2012
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.010 AlteredExpression disease BEFREE In this study, therefore, the effect of COPS3 silencing via COPS3 siRNA on lung cancer cell proliferation was examined. 22631635 2012