Hepatomegaly
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
|
28108177 |
2017 |
Osteosarcoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The amplification of gene COPS3 is closely related to the development of osteosarcoma and hepatocellular carcinoma.
|
31509289 |
2019 |
Osteosarcoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The effect of COPS3 on the metastasis of osteosarcoma cells was investigated by transwell, wound healing assays and animal studies.
|
29970115 |
2018 |
Osteosarcoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The COPS3 gene has stimulating effect on cell proliferation and progression of osteosarcomas and related cells.
|
22631635 |
2012 |
Osteosarcoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We conclude that these genes, including COPS3 and PMP22, are candidate oncogenes in 17p11.2-p12 of importance in osteosarcoma tumourigenesis.
|
22292074 |
2012 |
Osteosarcoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells.
|
21436869 |
2011 |
Osteosarcoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Amplification of COPS3, detected in 31% of the osteosarcomas, was strongly associated with large tumor size (P=.0009), but was not associated with age at diagnosis, site, sex, and tumor necrosis.
|
17366602 |
2007 |
Osteosarcoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of COPS3 has been linked to TP53 protein degradation and, being equivalent to TP53 mutation, the induction of genomic instability, which frequently occurs in high-grade osteosarcoma.
|
15325100 |
2004 |
Osteosarcoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We conclude that PMP22 and COPS3, and possibly also the three ESTs, are candidate amplification targets in 17p11.2 approximately p12 in osteosarcoma.
|
15193436 |
2004 |
Osteosarcoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We present detailed analysis of TP53 mutations and MDM2 and COPS3 expression levels in a set of 23 OS.
|
12917637 |
2003 |
Osteosarcoma of bone
|
0.070 |
Biomarker
|
disease |
BEFREE |
The amplification of gene COPS3 is closely related to the development of osteosarcoma and hepatocellular carcinoma.
|
31509289 |
2019 |
Childhood Osteosarcoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The amplification of gene COPS3 is closely related to the development of osteosarcoma and hepatocellular carcinoma.
|
31509289 |
2019 |
Osteosarcoma of bone
|
0.070 |
Biomarker
|
disease |
BEFREE |
The effect of COPS3 on the metastasis of osteosarcoma cells was investigated by transwell, wound healing assays and animal studies.
|
29970115 |
2018 |
Childhood Osteosarcoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The effect of COPS3 on the metastasis of osteosarcoma cells was investigated by transwell, wound healing assays and animal studies.
|
29970115 |
2018 |
Osteosarcoma of bone
|
0.070 |
Biomarker
|
disease |
BEFREE |
We conclude that these genes, including COPS3 and PMP22, are candidate oncogenes in 17p11.2-p12 of importance in osteosarcoma tumourigenesis.
|
22292074 |
2012 |
Childhood Osteosarcoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
We conclude that these genes, including COPS3 and PMP22, are candidate oncogenes in 17p11.2-p12 of importance in osteosarcoma tumourigenesis.
|
22292074 |
2012 |
Osteosarcoma of bone
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells.
|
21436869 |
2011 |
Childhood Osteosarcoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells.
|
21436869 |
2011 |
Osteosarcoma of bone
|
0.070 |
Biomarker
|
disease |
BEFREE |
COPS3 may function as an oncogene in osteosarcoma, and an increased copy number may lead to an unfavorable prognosis.
|
17366602 |
2007 |
Childhood Osteosarcoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
COPS3 may function as an oncogene in osteosarcoma, and an increased copy number may lead to an unfavorable prognosis.
|
17366602 |
2007 |
Osteosarcoma of bone
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of COPS3 has been linked to TP53 protein degradation and, being equivalent to TP53 mutation, the induction of genomic instability, which frequently occurs in high-grade osteosarcoma.
|
15325100 |
2004 |
Osteosarcoma of bone
|
0.070 |
Biomarker
|
disease |
BEFREE |
We conclude that PMP22 and COPS3, and possibly also the three ESTs, are candidate amplification targets in 17p11.2 approximately p12 in osteosarcoma.
|
15193436 |
2004 |
Childhood Osteosarcoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of COPS3 has been linked to TP53 protein degradation and, being equivalent to TP53 mutation, the induction of genomic instability, which frequently occurs in high-grade osteosarcoma.
|
15325100 |
2004 |
Childhood Osteosarcoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
We conclude that PMP22 and COPS3, and possibly also the three ESTs, are candidate amplification targets in 17p11.2 approximately p12 in osteosarcoma.
|
15193436 |
2004 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The effect of COPS3 on the metastasis of osteosarcoma cells was investigated by transwell, wound healing assays and animal studies.
|
29970115 |
2018 |