COPS3, COP9 signalosome subunit 3, 8533

N. diseases: 24; N. variants: 0
Disease: Osteosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 Biomarker disease BEFREE The amplification of gene COPS3 is closely related to the development of osteosarcoma and hepatocellular carcinoma. 31509289 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 Biomarker disease BEFREE The effect of COPS3 on the metastasis of osteosarcoma cells was investigated by transwell, wound healing assays and animal studies. 29970115 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 Biomarker disease BEFREE The COPS3 gene has stimulating effect on cell proliferation and progression of osteosarcomas and related cells. 22631635 2012
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 Biomarker disease BEFREE We conclude that these genes, including COPS3 and PMP22, are candidate oncogenes in 17p11.2-p12 of importance in osteosarcoma tumourigenesis. 22292074 2012
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 AlteredExpression disease BEFREE Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. 21436869 2011
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 Biomarker disease BEFREE Amplification of COPS3, detected in 31% of the osteosarcomas, was strongly associated with large tumor size (P=.0009), but was not associated with age at diagnosis, site, sex, and tumor necrosis. 17366602 2007
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 AlteredExpression disease BEFREE Overexpression of COPS3 has been linked to TP53 protein degradation and, being equivalent to TP53 mutation, the induction of genomic instability, which frequently occurs in high-grade osteosarcoma. 15325100 2004
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 Biomarker disease BEFREE We conclude that PMP22 and COPS3, and possibly also the three ESTs, are candidate amplification targets in 17p11.2 approximately p12 in osteosarcoma. 15193436 2004
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.090 AlteredExpression disease BEFREE We present detailed analysis of TP53 mutations and MDM2 and COPS3 expression levels in a set of 23 OS. 12917637 2003