COPS3, COP9 signalosome subunit 3, 8533

N. diseases: 24; N. variants: 0
Disease: Childhood Osteosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 Biomarker disease BEFREE The amplification of gene COPS3 is closely related to the development of osteosarcoma and hepatocellular carcinoma. 31509289 2019
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 Biomarker disease BEFREE The effect of COPS3 on the metastasis of osteosarcoma cells was investigated by transwell, wound healing assays and animal studies. 29970115 2018
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 Biomarker disease BEFREE We conclude that these genes, including COPS3 and PMP22, are candidate oncogenes in 17p11.2-p12 of importance in osteosarcoma tumourigenesis. 22292074 2012
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 AlteredExpression disease BEFREE Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. 21436869 2011
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 Biomarker disease BEFREE COPS3 may function as an oncogene in osteosarcoma, and an increased copy number may lead to an unfavorable prognosis. 17366602 2007
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 AlteredExpression disease BEFREE Overexpression of COPS3 has been linked to TP53 protein degradation and, being equivalent to TP53 mutation, the induction of genomic instability, which frequently occurs in high-grade osteosarcoma. 15325100 2004
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.070 Biomarker disease BEFREE We conclude that PMP22 and COPS3, and possibly also the three ESTs, are candidate amplification targets in 17p11.2 approximately p12 in osteosarcoma. 15193436 2004