|
HIV Infections
|
0.330 |
Biomarker
|
group |
BEFREE |
Meta-analyses of large cohort studies have identified numerous 'AIDS restriction genes' that regulate HIV cell entry (particularly chemokine coreceptors and their ligands), acquired and innate immunity (major histocompatibility complex, killer cell immunoglobulin-like receptor, and cytokines), and others [tripartite interaction motif 5 alpha (TRIM5alpha) and apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G] that influence outcome of HIV infection.
|
19317737 |
2009 |
|
HIV Infections
|
0.330 |
GeneticVariation
|
group |
BEFREE |
Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection.
|
16887163 |
2006 |
|
HIV Infections
|
0.330 |
Therapeutic
|
group |
CTD_human |
The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities.
|
15249687 |
2004 |
|
HIV Infections
|
0.330 |
Biomarker
|
group |
LHGDN |
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.
|
14985764 |
2004 |
|
HIV Coinfection
|
0.300 |
Therapeutic
|
disease |
CTD_human |
The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities.
|
15249687 |
2004 |
|
Retroviridae Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
One example is the tripartite motif-containing protein 5 alpha (TRIM5α), a cytoplasmic factor that restricts retroviral infection in a species-specific fashion.
|
31830084 |
2019 |
|
Platelet Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Alkaline phosphatase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both forms of TRIM5 therefore use the same mechanism of avidity-driven capsid pattern recognition.<b>IMPORTANCE</b> Rhesus macaques and owl monkeys are highly resistant to HIV-1 infection due to the activity of TRIM5 restriction factors.
|
29187540 |
2018 |
|
Polybrominated biphenyl measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants.
|
28235828 |
2017 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicate that CypA inhibits HIV-1 infection in Vero cells not by promoting TRIM5α binding to the capsid but by blocking nuclear import of the HIV-1 preintegration complex.
|
28767697 |
2017 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1.
|
27083474 |
2017 |
|
Pharyngeal Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
|
27749845 |
2016 |
|
Malignant neoplasm of floor of mouth
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
|
27749845 |
2016 |
|
Malignant neoplasm of anterior portion of floor of mouth
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
|
27749845 |
2016 |
|
Malignant neoplasm of other specified parts of mouth
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
|
27749845 |
2016 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
|
27749845 |
2016 |
|
Malignant neoplasm of other sites within the lip and oral cavity
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
|
27749845 |
2016 |
|
Platelet mean volume determination (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Malignant neoplasm of lateral floor of mouth
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
|
27749845 |
2016 |
|
Peripheral Arterial Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.
|
27082954 |
2016 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Human TRIM5 gene single nucleotide polymorphisms have been reported as involved in susceptibility to HIV-1 infection.
|
27388872 |
2016 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to analyze whether TRIM5 and TRIM22 polymorphisms are associated with liver fibrosis inflammation-related biomarkers and response to pegylated-interferon-alpha plus ribavirin (pegIFNα/RBV) therapy in HIV/hepatitis C virus (HCV) coinfected patients.
|
27590274 |
2016 |