|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Northern blot analysis showed that matrix metalloproteinase (MMP)-2 and membrane type 1 MMP (MT1-MMP) genes were found to be expressed in high levels in AAC-11-transfected cancer cells.
|
10780674 |
2000 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Northern blot analysis showed that matrix metalloproteinase (MMP)-2 and membrane type 1 MMP (MT1-MMP) genes were found to be expressed in high levels in AAC-11-transfected cancer cells.
|
10780674 |
2000 |
|
Malignant tumor of cervix
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that AAC-11 may serve as a candidate metastasis-related and apoptosis-inhibiting gene in human cervical cancer.
|
10780674 |
2000 |
|
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that AAC-11 may serve as a candidate metastasis-related and apoptosis-inhibiting gene in human cervical cancer.
|
10780674 |
2000 |
|
cervical cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that AAC-11 may serve as a candidate metastasis-related and apoptosis-inhibiting gene in human cervical cancer.
|
10780674 |
2000 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Invasion of matrigel and adhesion to laminin by AAC-11 transfected CUMC-6 cells were increased by approximately 2-fold and 4-fold, respectively.
|
10780674 |
2000 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
AAC-11 transcripts were detected in 12 (12.7%) of the tumor samples, although five of paired normal lung samples showed very weak expression.
|
11557113 |
2001 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Although the AAC-11 gene was not expressed in a majority of NSCLC tumors, we suggest that AAC-11 may predict poor survival.
|
11557113 |
2001 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
AAC-11 was preferentially expressed in squamous cell carcinoma (26.9% of squamous cell carcinoma vs. 7% of adenocarcinoma).
|
11557113 |
2001 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
AAC-11 was preferentially expressed in squamous cell carcinoma (26.9% of squamous cell carcinoma vs. 7% of adenocarcinoma).
|
11557113 |
2001 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Significantly, miR-224 expression was found to be inversely correlated with API-5 expression in HCC patients (p < 0.05).
|
18319255 |
2008 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Pim-2 activates API-5 to inhibit the apoptosis of hepatocellular carcinoma cells through NF-kappaB pathway.
|
19821157 |
2010 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The recent report of efficient AAC-11 inhibiting peptides that sensitize tumor cells to chemotherapeutic drugs has raise the exciting notion that AAC-11 might be a druggable target and fueled the search for new therapeutic agents that could block AAC-11 function.
|
20001210 |
2010 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Blocking AAC-11 function in cancer for therapeutic purposes might be of great interest.
|
20001210 |
2010 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Blocking AAC-11 function in cancer for therapeutic purposes might be of great interest.
|
20001210 |
2010 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This retrospective study indicates that CSNK2A1 and AAC-11, especially in combination, are useful prognosis markers in NSCLC patients after complete resection, independent of lymph node metastasis status.
|
20671611 |
2010 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
To analyze the prognostic significance of the genes casein kinase 2 alpha subunit (CSNK2A1), anti-apoptosis clone-11 (AAC-11), and tumor metastasis suppressor NME1 in completely resected non-small cell lung cancer (NSCLC) patients.
|
20671611 |
2010 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
This retrospective study indicates that CSNK2A1 and AAC-11, especially in combination, are useful prognosis markers in NSCLC patients after complete resection, independent of lymph node metastasis status.
|
20671611 |
2010 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
To analyze the prognostic significance of the genes casein kinase 2 alpha subunit (CSNK2A1), anti-apoptosis clone-11 (AAC-11), and tumor metastasis suppressor NME1 in completely resected non-small cell lung cancer (NSCLC) patients.
|
20671611 |
2010 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Treatment of human MCF-7 cells with tocotrienol isomers causes the down-regulation of the API5 gene and up-regulation of the MIG6 gene and the differential expression of other genes reported to play a key role in breast cancer biology.
|
21289334 |
2011 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Treatment of human MCF-7 cells with tocotrienol isomers causes the down-regulation of the API5 gene and up-regulation of the MIG6 gene and the differential expression of other genes reported to play a key role in breast cancer biology.
|
21289334 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We further found that STAT1 mRNA targeted by miR-145 was over-expressed and apoptosis inhibitory protein 5 (API5) mRNA targeted by miR-224 was under-expressed in SLE T cells.
|
23199328 |
2013 |
|
Lupus Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These miRNA aberrations accelerated T cell activation-induced cell death by suppressing API5 expression and associated with lupus nephritis by enhancing signal transducer and activator of transcription-1 (STAT)-1 expression in patients with SLE.
|
23199328 |
2013 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Its RNAi-mediated silencing in tumor cells expressing high levels of API5 restored antigen-specific immune sensitivity.
|
24769442 |
2014 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further, siRNA mediated down-regulation of API5 was also found to have radiation sensitizing effect on glioblastoma cell lines.
|
24785373 |
2014 |