|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Thus, our findings reveal a crucial role of API5 in linking immune resistance and CSC-like properties, and provide the rationale for its therapeutic application for the treatment of API5<sup>+</sup> refractory tumors.
|
28092370 |
2017 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Besides, Api5 expression favors tumorigenicity and migration and is necessary for tumor growth <i>in vivo</i> in mice xenografted model of breast cancer cell line.
|
28881748 |
2017 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Furthermore, within early stage tumours (I/II), high expression of API5, CHI3L1 and FASN was associated with high tumour grade (p = 3 × 10(-4) , p = 0.016, p = 0.010, respectively).
|
25204737 |
2015 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Its RNAi-mediated silencing in tumor cells expressing high levels of API5 restored antigen-specific immune sensitivity.
|
24769442 |
2014 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The recent report of efficient AAC-11 inhibiting peptides that sensitize tumor cells to chemotherapeutic drugs has raise the exciting notion that AAC-11 might be a druggable target and fueled the search for new therapeutic agents that could block AAC-11 function.
|
20001210 |
2010 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
AAC-11 transcripts were detected in 12 (12.7%) of the tumor samples, although five of paired normal lung samples showed very weak expression.
|
11557113 |
2001 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
We previously reported that a peptide, called RT53, spanning the heptad leucine repeat region of the survival protein AAC-11 fused to a penetrating sequence, selectively induces cancer cell death in vitro and in vivo.
|
30080874 |
2018 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
We previously reported that a peptide, called RT53, spanning the heptad leucine repeat region of the survival protein AAC-11 fused to a penetrating sequence, selectively induces cancer cell death in vitro and in vivo.
|
30080874 |
2018 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Finally, we found that the blockade of FGFR signaling is an effective strategy to control API5<sup>high</sup> human cancer.
|
28092370 |
2017 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Api5 (Apoptosis inhibitor 5) is an anti-apoptotic factor that confers resistance to genotoxic stress in human cancer.
|
28881748 |
2017 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Api5 (Apoptosis inhibitor 5) is an anti-apoptotic factor that confers resistance to genotoxic stress in human cancer.
|
28881748 |
2017 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Finally, we found that the blockade of FGFR signaling is an effective strategy to control API5<sup>high</sup> human cancer.
|
28092370 |
2017 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Blocking AAC-11 function in cancer for therapeutic purposes might be of great interest.
|
20001210 |
2010 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Blocking AAC-11 function in cancer for therapeutic purposes might be of great interest.
|
20001210 |
2010 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Northern blot analysis showed that matrix metalloproteinase (MMP)-2 and membrane type 1 MMP (MT1-MMP) genes were found to be expressed in high levels in AAC-11-transfected cancer cells.
|
10780674 |
2000 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Northern blot analysis showed that matrix metalloproteinase (MMP)-2 and membrane type 1 MMP (MT1-MMP) genes were found to be expressed in high levels in AAC-11-transfected cancer cells.
|
10780674 |
2000 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In ERα breast cancer patients, Api5 overexpression is associated with poor survival, and may be used as a predictive marker of breast cancer recurrence free survival.
|
28881748 |
2017 |
|
Malignant tumor of cervix
|
0.020 |
Biomarker
|
disease |
BEFREE |
Since we found that API5 expression was positively correlated with chemotherapy resistance in several specimens from patients with cervical cancer, we decided to investigate whether API5 is involved in the development of resistance after chemotherapy and to explore whether targeting API5 or its downstream effectors can reverse chemo-resistance.
|
28883546 |
2017 |
|
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Since we found that API5 expression was positively correlated with chemotherapy resistance in several specimens from patients with cervical cancer, we decided to investigate whether API5 is involved in the development of resistance after chemotherapy and to explore whether targeting API5 or its downstream effectors can reverse chemo-resistance.
|
28883546 |
2017 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In ERα breast cancer patients, Api5 overexpression is associated with poor survival, and may be used as a predictive marker of breast cancer recurrence free survival.
|
28881748 |
2017 |
|
cervical cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
Since we found that API5 expression was positively correlated with chemotherapy resistance in several specimens from patients with cervical cancer, we decided to investigate whether API5 is involved in the development of resistance after chemotherapy and to explore whether targeting API5 or its downstream effectors can reverse chemo-resistance.
|
28883546 |
2017 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Treatment of human MCF-7 cells with tocotrienol isomers causes the down-regulation of the API5 gene and up-regulation of the MIG6 gene and the differential expression of other genes reported to play a key role in breast cancer biology.
|
21289334 |
2011 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Treatment of human MCF-7 cells with tocotrienol isomers causes the down-regulation of the API5 gene and up-regulation of the MIG6 gene and the differential expression of other genes reported to play a key role in breast cancer biology.
|
21289334 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This retrospective study indicates that CSNK2A1 and AAC-11, especially in combination, are useful prognosis markers in NSCLC patients after complete resection, independent of lymph node metastasis status.
|
20671611 |
2010 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Pim-2 activates API-5 to inhibit the apoptosis of hepatocellular carcinoma cells through NF-kappaB pathway.
|
19821157 |
2010 |