APOL1, apolipoprotein L1, 8542

N. diseases: 115; N. variants: 9
Disease: African Trypanosomiasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 GeneticVariation disease BEFREE No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations. 29470556 2018
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 Biomarker disease BEFREE APOL1 kills the bloodstream parasite Trypanosoma brucei brucei, but not the human sleeping sickness agents T.b. rhodesiense and T.b. gambiense <sup>3</sup> . 28924146 2017
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 GeneticVariation disease BEFREE African Americans are disproportionately affected by the disease, and recently discovered genetic variants in APOL1 that protect against sleeping sickness in Africa provide an important explanation for the increased burden. 29173252 2017
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 Biomarker disease BEFREE Subspecies of T b brucei that cause human sleeping sickness-T b gambiense and T b rhodesiense evolved molecular mechanisms that enabled them to evade killing by APOL1. 29110762 2017
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 Biomarker disease BEFREE Trypanosomes that cause sleeping sickness endocytose apolipoprotein L1 (APOL1)-containing trypanolytic factors from human serum, leading to trypanolytic death through generation of APOL1-associated lytic pores in trypanosomal membranes. 26945671 2016
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 Biomarker disease BEFREE The human-infective trypanosomes, Trypanosoma brucei rhodesiense in East Africa and T. b. gambiense in West Africa have separately evolved mechanisms that allow them to resist APOL1-mediated lysis and cause human African trypanosomiasis, or sleeping sickness, in man. 27494254 2016
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 GeneticVariation disease BEFREE Two APOL1 gene variants, which likely evolved to protect individuals from African sleeping sickness, are strongly associated with nondiabetic kidney disease in individuals with recent African ancestry. 26089538 2015
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 GeneticVariation disease BEFREE However, taken together with alleles of APOL1, there is an overall significant undertransmission of putative protective alleles to human African trypanosomiasis-affected children. 24005574 2014
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 GeneticVariation disease BEFREE APOL1 genetic variants strongly associated with kidney disease in African Americans have additional trypanolytic activity against Trypanosoma brucei rhodesiense, the cause of acute African sleeping sickness. 24808134 2014
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 GeneticVariation disease BEFREE In the prevailing hypothesis, heterozygous APOL1 G1 and G2 alleles increase resistance against Trypanosoma that cause African sleeping sickness, resulting in positive selection of these alleles, but when homozygous the G1 and G2 alleles predispose to glomerulosclerosis. 23300552 2012
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 GeneticVariation disease BEFREE APOL1 nephropathy risk variants persist because of protection afforded from the parasite that causes African sleeping sickness. 22068337 2012
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 GeneticVariation disease BEFREE Alterations in ApoL1 function due to genetic, environmental, and lifestyle factors have been associated with African sleeping sickness, atherosclerosis, lipid disorders, obesity, schizophrenia, cancer, and chronic kidney disease (CKD). 22569246 2012
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 GeneticVariation disease BEFREE Based on this last observation we hypothesised that variation in the host APOL1 environment could significantly alter T. b. gambiense growth and thus resistance/susceptibility to sleeping sickness. 22691369 2012
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 GeneticVariation disease BEFREE The powerful evolutionary selection pressure of an infectious pathogen in West Africa favored the spread of APOL1 variants that protect against a lethal form of African sleeping sickness but are highly associated with an increased risk of kidney disease. 21537348 2011
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.100 Biomarker disease BEFREE Elucidation of the process by which Trypanosoma brucei rhodesiense resists lysis and causes human sleeping sickness has indicated that the HDL-bound apolipoprotein L-I (apoL-I) could be the long-sought after lytic component of NHS. 15217727 2004