Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Clinical trials support a central role for TSLP in driving airway inflammation and asthma exacerbations, while ongoing trials blocking IL-33 and IL-25 will help to define their respective role in asthma.
|
31408015 |
2020 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our study demonstrated an increased expression of TSLP and IL-33 receptors on bronchial CD206 positive macrophages in asthma group.
|
30588853 |
2020 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Indeed, TSLP can condition dendritic cells to initiate type 2 responses, and IL-33 may influence susceptibility to asthma through its role in establishing the immune environment in the perinatal lungs.
|
30932910 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Tezepelumab (AMG 157) is a monoclonal antibody that targets thymic stromal lymphopoietin and has shown benefits in treating asthma.
|
30779339 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In order to further investigate the role of TSLP in the pathogenesis of TDI-induced asthma, a mouse model of TDI-induced asthma was also employed.
|
31577921 |
2019 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
To examine IL-25, IL-33 and TSLP levels in the EBC obtained from patients with IPF and compare them to those in healthy controls, patients with asthma and chronic obstructive pulmonary disease (COPD).
|
31392802 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Combined blockade of IL-25, IL-33 and TSLP mediates amplified inhibition of airway inflammation and remodelling in a murine model of asthma.
|
31610614 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several unanswered questions concerning basic pathophysiological aspects of TSLP variants, the long-term safety and efficacy of tezepelumab with different phenotypes/endotypes of asthma should be addressed.
|
31549891 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The serum OX40L level showed a significant positive correlation with serum IgE, blood percentages of eosinophils and neutrophils, serum IL-6 and TSLP, and showed a negative correlation with asthma control test (ACT) score and forced expiratory volume in first second (FEV1%).
|
30890137 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, this study aimed to determine the associations of IL1RL1 rs3771180 and TSLP rs1837253 with asthma in Zhuang people.
|
31066119 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data highlight the importance of TSLP in IL-37-mediated protective role in asthma.
|
30537285 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) plays an important role in allergic disorders, including atopic dermatitis and asthma.
|
30976816 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP), an epithelial-derived cytokine, was a key component in airway immunological response in asthma.
|
31378088 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
It has been revealed that pro-inflammatory cytokines such as IFN-γ, TNF-α, TGF-β, IL-17A, IL-27, IL-33 and thymic stromal lymphopoietin (TSLP) may contribute to steroid resistance in severe asthma and COPD.
|
31078066 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This asthma phenotype depends on interleukin (IL)-13-producing type 2 innate lymphoid cells, the expansion of which in turn depends on release of the innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin from the airway epithelium.
|
31284925 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data suggest that CCL17 and CCL22 produced by TSLP-primed naïve CD4<sup>+</sup> T cells in asthma might contribute to an increase in Th2 cells via autocrine loops.
|
30431203 |
2019 |
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The mean protein levels of TSLP and IL-33 from BAL fluid of asthmatic mice were significantly higher until 7 days.
|
30861490 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study examined the effect of an anti-TSLP antibody on MMP, CTGF, TGF-β, and airway structural changes in airway remodeling in asthma.
|
30464333 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic inflammation-related conditions such as asthma.
|
31275312 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Bronchial epithelial cell activation and release of cytokines, such as IL-33, IL-25 and TSLP play a major role in asthma.
|
31703832 |
2019 |
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several monoclonal antibodies (mAbs) targeting pathogenetic molecules (e.g., IgE, IL-5, IL- 5Rα, IL-4, IL-13, TSLP) are currently available or under development for the treatment of different forms of severe type 2 asthma.
|
29318959 |
2019 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) is associated with several allergic diseases including asthma.
|
29343779 |
2018 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) is an important factor responsible for the pathogenesis of allergic diseases, such as atopic dermatitis and asthma.
|
30011850 |
2018 |
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The expressions of periostin in NPs with asthma were higher than without asthma and the control nasal mucosa and positively associated with the TSLP (P<0.05).
|
30746204 |
2018 |