Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some research has reported that thymic stromal lymphopoietin (TSLP) may be a potential therapeutic target for the treatment of AD.
|
31313888 |
2020 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) plays an important role in allergic disorders, including atopic dermatitis and asthma.
|
30976816 |
2019 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, our results showed that the PUL extract could be effective for alleviating pruritus, and the antipruritic effects were exerted probably via the inhibition of the TSLP pathway in peripheral sensory neurons governing the itch sensation in AD.
|
31325512 |
2019 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In line with the in vitro results, Rh2 inhibited TSLP levels in AD mice via regulation of an underlying mechanism involving the nuclear factor κB pathways.
|
31817146 |
2019 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Oral administration of physcion improved the severity of 2,4-dinitrochlorobenzene-induced AD-like lesional skin through reducing infiltration of inflammatory cells and mast cells, and the protein and mRNA levels of TSLP, IL-4, and IL-6 in the lesional skin tissues.
|
30991764 |
2019 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Keratinocyte-derived cytokines, including thymic stromal lymphopoietin (TSLP) and IL-33, are considered to induce the development of AD.
|
31301371 |
2019 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tezepelumab (AMG 157/MEDI9929), a first-in-class monoclonal antibody, targets thymic stromal lymphopoietin, a cytokine that is implicated in the pathogenesis of atopic dermatitis (AD).
|
30550828 |
2019 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Osthole treatment alleviates atopic dermatitis through directly down-regulating TSLP production from keratinocytes.
|
30825337 |
2019 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TSLP variation was determined using targeted massively parallel sequencing in a longitudinal cohort of children with AD.
|
31491540 |
2019 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, such as atopic dermatitis and psoriasis.
|
29279286 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found that eupatilin suppressed the levels of serum immunoglobulin E (IgE), interleukin-4 (IL-4), and AD involved cytokines, such as tumor necrosis factor α (TNFα), interferon-γ (IFN-γ), IL-1β, and thymic stromal lymphopoietin (TSLP), IL-33, IL-25 and increased the levels of filaggrin and loricrin in the oxazolone-induced AD-like mouse model.
|
29353040 |
2018 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, AS significantly suppressed serum levels of histamine and IgE, while Bu-OH significantly suppressed serum levels of histamine, IgE, thymic stromal lymphopoietin (TSLP), interleukin (IL)-4 and IL-6, and DEQA significantly suppressed serum levels of histamine, IgE, TSLP and IL-4 in DNFB-induced AD mice.
|
29740850 |
2018 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TSLP is highly expressed in keratinocytes under inflammatory conditions, which suggests that it may play a critical role in the development of skin diseases, such as atopic dermatitis.
|
29310423 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Strategies to target the TSLP-basophil-IL-4 axis in patients with AD might lead to innovative therapies that can prevent the progression of allergies to distant mucosal sites.
|
28390860 |
2018 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, cordycepin reduced thymic stromal lymphopoietin (TSLP), interleukin (IL)-4, IL-6, and tumor necrosis factor-α levels in the serum of AD mice.
|
30183461 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this article, we will focus on the cytokines, interleukin (IL)-17, IL-19, IL-33, and TSLP (thymic stromal lymphopoietin), which play a significant role in AD pathogenesis and may become the targets for future biologic therapies in AD.
|
30304837 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the efficacy of MMB as a novel JAK1/JAK2 inhibitor in DNCB-induced AD mice and TSLP-activated dendritic cells.
|
30544712 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
These beneficial effects of EGF on AD may be mediated by EGF regulation of Th1/Th2-mediated cytokines, mast cell hyperplasia, and protease activated receptor-2 (PAR-2) and thymic stromal lymphopoietin (TSLP), which are triggers of AD.
|
30093649 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSLP has been originally implicated in a variety of allergic diseases (e.g., atopic dermatitis, bronchial asthma, eosinophilic esophagitis).
|
30057581 |
2018 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In mice, both EGF and pimecrolimus groups showed less erythema with significantly reduced inflammation and decreased expression of thymic stromal lymphopoietin.EGF relieved <i>S. aureus</i>-induced inflammation and AD-like skin lesions in Nc/Nga mice.
|
29862299 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
AST2017-01 and chrysophanol significantly suppressed the levels of histamine, immunoglobulin E, thymic stromal lymphopoietin (TSLP), interleukin (IL)-4, IL-6, and tumor necrosis factor-α in serum of AD mice.
|
30025384 |
2018 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These characteristics of AD-like lesions and thymic stromal lymphopoietin (TSLP) expression peaked at Day 1 of the establishment of our model and gradually alleviated over time.
|
30042397 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) plays an important role in the initiation and progress of skin inflammation and atopic dermatitis by triggering Th2 immune responses.
|
29462589 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
SP treatment significantly reduced the infiltration of mast cells and CD3-positive T cells as well as inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and thymic stromal lymphopoietin (TSLP), in AD-like skin lesions and decreased the levels of IgE and thymus and activation-regulated chemokine in serum.
|
28833499 |
2018 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Skin barrier disruption could induce thymic stromal lymphopoietin (TSLP) expression, and the expression of TSLP was increased in lesions of atopic dermatitis (AD)-like GVHD and lichen planus (LP)-like GVHD.
|
28584210 |
2017 |