|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In summary, we demonstrated that NOP14 inhibited melanoma cell proliferation and metastasis by regulating the Wnt/β-catenin signaling pathway.
|
30484495 |
2018 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
<i>In vivo</i>, high NOP14 expression in PDAC patient tumors correlated with local metastasis and lymph invasion.
|
28280038 |
2017 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells.
|
26213846 |
2015 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
NOP14 promotes proliferation and metastasis of pancreatic cancer cells.
|
22425761 |
2012 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Nucleolar protein 14 (NOP14) has been implicated in cancer development.
|
30484495 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Nucleolar protein 14 (NOP14) has been implicated in cancer development.
|
30484495 |
2018 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Targeting NOP14 allows for effective suppression of tumor invasion in a mutp53-dependent manner, implicating NOP14 inhibition as a potential approach for attenuating metastasis in p53-mutant tumors.<i>Cancer Res; 77(10); 2661-73.©2017 AACR</i>.
|
28280038 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Targeting NOP14 allows for effective suppression of tumor invasion in a mutp53-dependent manner, implicating NOP14 inhibition as a potential approach for attenuating metastasis in p53-mutant tumors.<i>Cancer Res; 77(10); 2661-73.©2017 AACR</i>.
|
28280038 |
2017 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development.
|
26213846 |
2015 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development.
|
26213846 |
2015 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Moreover, we observed that NOP14 expression was significantly associated with melanoma tumor thickness and lymph node metastasis.
|
30484495 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
NOP14 overexpression in melanoma cells suppressed proliferation, caused G1 phase arrest, promoted apoptosis, and inhibited melanoma cell migration and invasion.
|
30484495 |
2018 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
<i>In vivo</i>, high NOP14 expression in PDAC patient tumors correlated with local metastasis and lymph invasion.
|
28280038 |
2017 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
<i>In vivo</i>, high NOP14 expression in PDAC patient tumors correlated with local metastasis and lymph invasion.
|
28280038 |
2017 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, we demonstrated that NOP14 inhibited melanoma cell proliferation and metastasis by regulating the Wnt/β-catenin signaling pathway.
|
30484495 |
2018 |
|
Melanocytic nevus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we observed that malignant melanoma tissue showed NOP14 down-regulation compared to melanocytic nevi tissues.
|
30484495 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we observed that NOP14 expression was significantly associated with melanoma tumor thickness and lymph node metastasis.
|
30484495 |
2018 |
|
Melanocytic nevus of skin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we observed that malignant melanoma tissue showed NOP14 down-regulation compared to melanocytic nevi tissues.
|
30484495 |
2018 |
|
Miscarriage
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We performed exome sequencing using DNA from a miscarriage tissue and identified a homozygous NOP14 missense variant (c.[136C>G];[136C>G]) in both families.
|
29440706 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, our findings define a novel mechanism for understanding the function of NOP14 in the metastatic cascade of PDAC.
|
28280038 |
2017 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.
|
26213846 |
2015 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells.
|
26213846 |
2015 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.
|
26213846 |
2015 |
|
Invasive carcinoma of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues.
|
26213846 |
2015 |