RUNX1, RUNX family transcription factor 1, 861

N. diseases: 412; N. variants: 75
Disease: Hematological Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018939
Disease: Hematological Disease
Hematological Disease 		0.030 GeneticVariation group BEFREE In addition, many hematological diseases like myelodysplastic syndrome and myeloproliferative neoplasms have been associated with mutations in RUNX1. 22201794 2012
CUI: C0018939
Disease: Hematological Disease
Hematological Disease 		0.030 AlteredExpression group BEFREE Although the RUNX-1 gene is localized outside the deleted region, we speculate that RUNX-1 reduced expression, is probably due to the deletion of regulatory factors and caused the hematologic disorder in the patient. 21671372 2011
CUI: C0018939
Disease: Hematological Disease
Hematological Disease 		0.030 AlteredExpression group BEFREE We conclude that the expression of ETV6/CBFA2 alone is not sufficient for induction of growth factor independence in hematopoietic cell lines or hematologic disease in transgenic mice. 11675129 2001