|
Influenza
|
0.300 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
|
C-reactive protein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
|
30388399 |
2018 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
|
23300278 |
2013 |
|
C-reactive protein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
|
23844046 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
|
Pseudocholinesterase Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
|
21943158 |
2011 |
|
Serum gamma-glutamyl transferase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
|
21943158 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
Virus Diseases
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The mRNA expression levels of IL-1β, IL-6, IL-8, IFNs, TNF-α, Mx, and OASL were significantly upregulated during the viral infection.
|
31288442 |
2019 |
|
Virus Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
These results implicate that OASL1 plays context dependent functions in the antiviral response for the clearance and resolution of viral infections.
|
29463066 |
2018 |
|
Virus Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Previous work has identified that following viral infection, type I IFN signaling induces the production of the 2'-5'-oligoadenylate synthetase (OAS) family, which include OAS1, OAS2, OAS3, and OAS-like (OASL) protein.
|
28580319 |
2017 |
|
Virus Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Oasl1-/- mice were resistant to viral infection because of the greater abundance of type I interferon, which suggests that OASL1 could be a potential therapeutic target for boosting the production of type I interferon during viral infection.
|
23416614 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.030 |
Biomarker
|
disease |
BEFREE |
In this study, we assessed the values of expression levels of five type I interferon (IFN)-inducible genes (LY6E, OAS1, OASL, MX1, and ISG15) and total IFN score for the diagnosis of SLE.
|
25344775 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.030 |
Biomarker
|
disease |
BEFREE |
The mRNA expressions of OAS1, OAS2, and OASL were higher in patients with lupus flares than those with infections (p<0.03), or normal controls (p<0.001).
|
16565890 |
2007 |
|
Lupus Erythematosus, Systemic
|
0.030 |
Biomarker
|
disease |
BEFREE |
To study 5 type I interferon (IFN)-inducible genes (LY6E, OAS1, OASL, MX1, and ISG15) in patients with systemic lupus erythematosus (SLE) and to correlate expression levels with disease activity and/or clinical manifestations.
|
16947629 |
2006 |
|
Hepatitis C
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, OASL possesses two domains with HCV inhibitory activity.
|
20074559 |
2010 |
|
Hepatitis C
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that OASL variants are involved in the host response to IFN-based therapy in HCV patients.
|
18571276 |
2008 |
|
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The association between ISG15, OASL and IRF7 and TB infection was also verified.
|
31364746 |
2019 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, our data indicate that OASL can be one of the decisive regulators to maintain lung cancer cell susceptibility to acRoots and may be associated with the development of drug resistance.
|
29508110 |
2018 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, our data indicate that OASL can be one of the decisive regulators to maintain lung cancer cell susceptibility to acRoots and may be associated with the development of drug resistance.
|
29508110 |
2018 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, our data indicate that OASL can be one of the decisive regulators to maintain lung cancer cell susceptibility to acRoots and may be associated with the development of drug resistance.
|
29508110 |
2018 |