NCOA1, nuclear receptor coactivator 1, 8648

N. diseases: 108; N. variants: 7
Disease: Generalized Thyroid Hormone Resistance ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4722330
Disease: Generalized Thyroid Hormone Resistance
Generalized Thyroid Hormone Resistance 		0.030 Biomarker disease BEFREE We hypothesized that Src-1(-/-) mice have RTH due to unopposed corepressor action. 24550004 2014
CUI: C4722330
Disease: Generalized Thyroid Hormone Resistance
Generalized Thyroid Hormone Resistance 		0.030 Biomarker disease BEFREE Candidate genes were then evaluated for their possible involvement in the RTH phenotype in these 4 families: 2 coactivators [NCoA-1 (SRC-1) and NCoA-3 (AIB-1)], 2 corepressors (NCoR and SMRT), and a coregulator (RXRgamma). 11061510 2000
CUI: C4722330
Disease: Generalized Thyroid Hormone Resistance
Generalized Thyroid Hormone Resistance 		0.030 GeneticVariation disease BEFREE To determine the mechanism of RTH caused by these mutants, the interaction of wild type (wt) and mutant TRs with the corepressor, NCoR, and the coactivator, SRC-1, was tested in gel-shift assays. 9804773 1998