|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It has also been shown to play a role in the pathogenesis of certain cancers, although it remains controversial whether NUMB functions as an oncoprotein or tumor suppressor.
|
30726988 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NUMB, and its close homologue NUMBL, behave as tumor suppressor genes by regulating the Notch pathway.
|
29507685 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Among the 3 genes, PRR(L) form of NUMB gene is highly expressed in TT and positively correlated with tumor size, while PRR(S) is lacking in TT and negatively correlated with NOTCH expression suggesting that PRR(S) might be protective in tumorogenesis and shows NOTCH pathway down regulation ability.
|
26261495 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The NUMB, a tumor suppressor, in conjunction with another tumor-suppressor protein, p53, preserves this property and acts as a barrier against deregulated expansion of tumor-associated stem cells.
|
26174965 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our findings suggested NUMB-1 functions as a tumor-suppressor and serves as a prognositc biomarker for ESCC patients; thus, NUMB-1 may be a potential novel therapeutic target for treatment of ESCC.
|
24980814 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, treatment of colorectal cancer cells with anti-NOTCH2/3 antibody increased NUMB protein while significantly reducing formation of tumor cell spheroids.
|
24525742 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NUMB, well-known tumor suppressor gene, is a novel interacting partner of TRPV6.
|
24704446 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NUMB alternative splicing, which is frequently altered in lung cancer, can regulate colony and xenograft tumor formation, and its modulation recapitulates or antagonizes the effects of RBM5, 6, and 10 in cell colony formation.
|
24332178 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A miR-146a blocker abrogates the growth of xenograft tumors. miR-146a oncogenic activity is associated with down-regulation of IRAK1, TRAF6 and NUMB expression.
|
24302991 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Numb protein is a cell fate determinant that functions in endocytosis and as a tumor suppressor via the stabilization of p53.
|
23140583 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We thus show that in experimental gliomas, NUMB overexpression most likely does not exert a tumor suppressor function such as seen in epithelial cancers.
|
21939656 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, short hairpin RNA (shRNA) knockdown of NUMB followed by isoform-specific rescue revealed that expression of the exon 9-skipped (nontumor) isoform represses Notch target gene activation whereas expression of the exon 9-included (tumor) isoform lacks this activity and is capable of promoting cell proliferation.
|
21041478 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There might be, however, additional functions of NUMB, as witnessed by its proposed role as a tumour suppressor in breast cancer.
|
18172499 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Human NUMB mRNA was expressed in placenta, ES cells, neural tissues, trachea, testis, uterus, thymus, coronary artery as well as in a variety of tumors, such as cervical cancer, tong tumor, brain tumor, colorectal and breast cancer.
|
16865239 |
2006 |