|
Adrenal Gland Pheochromocytoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Two of the genes, epithelial membrane protein 3 (EMP3) and HSP47, demonstrated significantly more frequent methylation in neuroblastoma than phaeochromocytoma.
|
18499731 |
2008 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSP47 Promotes Glioblastoma Stemlike Cell Survival by Modulating Tumor Microenvironment Extracellular Matrix through TGF-β Pathway.
|
27696866 |
2017 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
Lysate virus particles on Western blot analysis revealed p19,p24, and p53 gag protein similar to those detected in C91/PL virus particles from an adult T-cell leukemia (ATL) patient. gp46 and gp61 were also weakly detected.
|
1520534 |
1992 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
Sequence analysis of an immunogenic and neutralizing domain of the human T-cell lymphoma/leukemia virus type I gp46 surface membrane protein among various primate T-cell lymphoma/leukemia virus isolates including those from a patient with both HTLV-I-associated myelopathy and adult T-cell leukemia.
|
8261424 |
1993 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
The envelope of human T-cell leukemia virus type I (HTLV-I) consists of two glycoproteins gp46 and p20E.
|
2078412 |
1990 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
The surface envelope glycoprotein gp46 of the human T cell leukemia virus type 1 elicits a strong immune response.
|
11242520 |
2001 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
A positive correlation between the appearance of an antibody recognizing the central region (Asp197 to Leu216) on Gp46, gp46-197, and the severity of ATL has been demonstrated.
|
19134004 |
2009 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
The primary protein product of the human T-cell leukemia virus type 1 (HTLV-1) env gene, gp61, is cleaved to produce both the exterior (gp46) and the transmembrane (gp21) portions of the HTLV-1 envelope protein.
|
2677406 |
1989 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
Chimeric synthetic peptides from the envelope (gp46) and the transmembrane (gp21) glycoproteins for the detection of antibodies to human T-cell leukemia virus type II.
|
11708768 |
2001 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further studies are warranted to determine if TBBPA increases the risk of adverse pregnancy outcomes such as preterm birth, pPROM and neurodevelopmental disorders such as autism that have been associated with increased production of proinflammatory cytokines, oxidative stress and/or T.
|
30055667 |
2018 |
|
Autoimmune Diseases
|
0.020 |
AlteredExpression
|
group |
LHGDN |
HSP47 antigen and autoantibody levels are significantly elevated in the sera of the rheumatic autoimmune disease patients, but not in the sera of the IPF patients.
|
12659832 |
2003 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
LHGDN |
The surface-exposed RA-A47 may induce autoantibodies and inflammatory reactions in autoimmune disease situations such as rheumatoid arthritis.
|
15389525 |
2005 |
|
Bacterial Endocarditis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Two isogenic strains of S. aureus, 1 carrying an insertional inactivation of the gene encoding collagen-binding protein, were compared in a rat model of catheter-induced infective endocarditis (i.e.).
|
8656018 |
1996 |
|
Bloom Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Morphological assessment showed that VA-lip-siRNA HSP47 also significantly improved the morphological pulmonary fibrosis of BLM-treated rats in both preventive and therapeutic schedules.
|
29035148 |
2018 |
|
Blue sclera
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Defining the role of common variation in the genomic and biological architecture of adult human height.
|
25282103 |
2014 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
|
25429064 |
2015 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
20881960 |
2010 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).
|
22021425 |
2012 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.
|
28270201 |
2017 |
|
Bone Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings will assist in the evaluation of roles of HSP47 in collagen misfolding and human diseases such as cancer and bone disorders.
|
30986427 |
2020 |
|
Bone Marrow Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
We synthesized 46 sequential peptides 21 to 39 amino acids long over the structural protein of human T-cell leukemia virus type I (HTLV-I; the p19 and p24 gag protein and the gp46 and p20E env proteins) and tested their reactivities against antibodies in sera from HTLV-I healthy carriers and patients diagnosed as having human T-cell leukemia-lymphoma (ATLL) and myelopathy (HAM) by using an enzyme-linked immunosorbent assay.
|
1537894 |
1992 |