SERPINH1, serpin family H member 1, 871

N. diseases: 148; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005940
Disease: Bone Diseases
Bone Diseases 		0.010 Biomarker group BEFREE These findings will assist in the evaluation of roles of HSP47 in collagen misfolding and human diseases such as cancer and bone disorders. 30986427 2020
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.010 Biomarker group BEFREE In this Review, we discuss the role and function of Hsp47 in vertebrate cells and its role in connective tissue disorders. 30541925 2019
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis 		0.010 Biomarker disease BEFREE HSP47 is increased in patients with CRS without nasal polyps. 31664133 2019
CUI: C0013238
Disease: Dry Eye Syndromes
Dry Eye Syndromes 		0.010 Biomarker disease BEFREE VA-lip HSP47 eye drops are a promising prophylactic and therapeutic option against dry eye syndrome in chronic GVHD. 30940635 2019
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease 		0.010 Biomarker disease BEFREE We explored the role of heat shock protein 47 (HSP47) in ocular GVHD and developed a novel antifibrotic topical therapy using vitamin A-coupled liposomes containing HSP47 small interfering RNA (siRNA) against HSP47 (VA-lip HSP47). 30940635 2019
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.010 Biomarker disease BEFREE HSP47 is increased in patients with CRS without nasal polyps. 31664133 2019
CUI: C0149516
Disease: Chronic sinusitis
Chronic sinusitis 		0.010 Biomarker disease BEFREE HSP47 is required for the production of collagen and serves an important role in tissue remodeling, a pathophysiologic mechanism of chronic rhinosinusitis (CRS). 31664133 2019
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.010 Biomarker disease BEFREE Further studies are warranted to determine if TBBPA increases the risk of adverse pregnancy outcomes such as preterm birth, pPROM and neurodevelopmental disorders such as autism that have been associated with increased production of proinflammatory cytokines, oxidative stress and/or T. 30055667 2018
CUI: C0005859
Disease: Bloom Syndrome
Bloom Syndrome 		0.010 Biomarker disease BEFREE Morphological assessment showed that VA-lip-siRNA HSP47 also significantly improved the morphological pulmonary fibrosis of BLM-treated rats in both preventive and therapeutic schedules. 29035148 2018
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.010 GeneticVariation disease BEFREE Women with endometriosis are at elevated risk for serious and important adverse maternal (pre-eclampsia, gestational diabetes, placenta praevia and Cesarean section) and fetal or neonatal outcomes (preterm birth, PPROM, small for gestational age, stillbirth and neonatal death). 30239732 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.010 Biomarker group BEFREE For example, the expression changing of SERPINH1 only appeared in the acute phase of stroke showing its targeting role in the combined biomarker. 30158363 2018
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.010 Biomarker disease BEFREE We have thus shown for the first time that SERPINH1 is an independent precision predictor for unfavourable prognosis in ccRCC. 29239102 2018
CUI: C1333964
Disease: Liver Dysplastic Nodule
Liver Dysplastic Nodule 		0.010 AlteredExpression disease BEFREE In DN, significantly higher mRNA expression of FBN1 (P=.014), SMAD7 (P=.019), HSP47 (P=.023), and SERPINE1 (P=.008), but a lower HSPA5 expression (P=.029), was observed than in HI. 29198452 2018
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.010 Biomarker phenotype BEFREE Studies have shown that HSP47 promotes tumor angiogenesis, growth, migration and metastatic capacity. 30128672 2018
CUI: C1535926
Disease: Neurodevelopmental Disorders
Neurodevelopmental Disorders 		0.010 Biomarker group BEFREE Further studies are warranted to determine if TBBPA increases the risk of adverse pregnancy outcomes such as preterm birth, pPROM and neurodevelopmental disorders such as autism that have been associated with increased production of proinflammatory cytokines, oxidative stress and/or T. 30055667 2018
CUI: C4048329
Disease: Immunosuppression
Immunosuppression 		0.010 AlteredExpression disease BEFREE VA-lip HSP47 knocked down HSP47 expression in myofibroblasts and significantly reduced collagen deposition without inducing systemic immunosuppression. 29363541 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 Biomarker disease BEFREE Their data indicate that the number of HSP47-positive spindle cells in the stroma of CRC may serve as a novel predictive biomarker of LN metastasis, early recurrence and poor prognosis. 27925182 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.010 Biomarker disease BEFREE HSP47 Promotes Glioblastoma Stemlike Cell Survival by Modulating Tumor Microenvironment Extracellular Matrix through TGF-β Pathway. 27696866 2017
CUI: C0023529
Disease: Leukomalacia, Periventricular
Leukomalacia, Periventricular 		0.010 Biomarker disease BEFREE <b>Conclusion</b> Preterm infants with HRF exposed to antenatal steroids and pPROM had improved oxygenation with iNO and survival without severe IVH/PVL. 27627792 2017
CUI: C0026946
Disease: Mycoses
Mycoses 		0.010 Biomarker group BEFREE We previously showed that the intracellular fungal pathogen Histoplasma capsulatum (Hc) uses the secreted protein Cbp1 to actively induce apoptosis in macrophages; interestingly, cbp1 mutant strains are unable to kill macrophages and display severely reduced virulence in the mouse model of Hc infection. 28953979 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE Their data indicate that the number of HSP47-positive spindle cells in the stroma of CRC may serve as a novel predictive biomarker of LN metastasis, early recurrence and poor prognosis. 27925182 2017
CUI: C0079680
Disease: Lentivirus Infections
Lentivirus Infections 		0.010 AlteredExpression group BEFREE The stable overexpression of HSP47 in primary GBM cells was established by lentivirus infection. 27696866 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.010 Biomarker disease BEFREE HSP47 Promotes Glioblastoma Stemlike Cell Survival by Modulating Tumor Microenvironment Extracellular Matrix through TGF-β Pathway. 27696866 2017
CUI: C0280324
Disease: Laryngeal Squamous Cell Carcinoma
Laryngeal Squamous Cell Carcinoma 		0.010 AlteredExpression disease BEFREE Upregulation of HSP47 via plasmid vectors inhibited the proliferation, reduced the invasive ability, increased the sensitivity to cisplatin chemotherapy, promoted apoptosis, and induced the G1 phase arrest of LSCC cells in vitro. 28849239 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.010 Biomarker disease BEFREE HSP47 Promotes Glioblastoma Stemlike Cell Survival by Modulating Tumor Microenvironment Extracellular Matrix through TGF-β Pathway. 27696866 2017